Evidence map›Paper›PMID 35496338›Full record

ArticleRSC advances2022

An

Leagh G Powell, Cameron Alexander, Vicki Stone, Helinor J Johnston, Claudia Conte

Abstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leagh G PowellNano Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University UK.
Cameron AlexanderDivision of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham UK.ORCID https://orcid.org/0000-0001-8337-1875
Vicki StoneNano Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University UK.
Helinor J JohnstonNano Safety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University UK.
Claudia ConteDepartment of Pharmacy, University of Naples Naples Italy claudia.conte@unina.it.ORCID https://orcid.org/0000-0002-3547-8085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It can be challenging to deliver drugs to cancer cells in a targeted manner at an effective dose. Polymeric nanoparticles (NPs) are promising drug delivery systems that can be targeted to cancer cells using redox responsive elements. More specifically, intracellular and extracellular levels of the antioxidant glutathione (GSH) are elevated in cancer cells and therefore the use of NPs with a cleavable GSH-responsive element allowing these NPs to target cancer cells and trigger the release of their cargo (

Identifiers

PMID35496338
PMCPMC9044528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.