Evidence map›Paper›PMID 35496306›Full record

ArticleFrontiers in pharmacology2022

Urinary Profile of Endogenous Gamma-Hydroxybutyric Acid and its Biomarker Metabolites in Healthy Korean Females: Determination of Age-Dependent and Intra-Individual Variability and Identification of Metabolites Correlated With Gamma-Hydroxybutyric Acid.

Suji Kim, Suein Choi, Min Seo Lee, Mingyu Kim, Maria Park, Sungpil Han, Seunghoon Han, Hye Suk Lee, Sooyeun Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Suji KimAnalytical Toxicology Laboratory, College of Pharmacy, Keimyung University, Daegu, South Korea.
Suein ChoiPharmacometrics Institute for Practical Education and Training, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Min Seo LeeDrug Metabolism and Bioanalysis Laboratory and BK21 Four-Sponsored Advanced Program for SmartPharma Leaders, College of Pharmacy, The Catholic University of Korea, Bucheon, South Korea.
Mingyu KimAnalytical Toxicology Laboratory, College of Pharmacy, Keimyung University, Daegu, South Korea.
Maria ParkPharmacometrics Institute for Practical Education and Training, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Sungpil HanPharmacometrics Institute for Practical Education and Training, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Seunghoon HanPharmacometrics Institute for Practical Education and Training, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Hye Suk LeeDrug Metabolism and Bioanalysis Laboratory and BK21 Four-Sponsored Advanced Program for SmartPharma Leaders, College of Pharmacy, The Catholic University of Korea, Bucheon, South Korea.
Sooyeun LeeAnalytical Toxicology Laboratory, College of Pharmacy, Keimyung University, Daegu, South Korea.
Catholic University of Korea · KRKeimyung University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gamma-hydroxybutyric acid (GHB), used as a therapeutic and an illegal anesthetic, is a human neurotransmitter produced during gamma-aminobutyric acid (GABA) biosynthesis and metabolism. Potential biomarker metabolites of GHB intoxication have been identified previously; however, reference concentrations have not been set due to the lack of clinical study data. Urinary profiling of endogenous GHB and its biomarker metabolites in urine samples (

Indexed as

biomarker metabolitesgamma-hydroxybutyric acidliquid chromatography-tandem mass spectrometrymetabolite profilingurine

Identifiers

PMID35496306
PMCPMC9043528
OpenAlexW4223946143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.