Evidence map›Paper›PMID 35496281›Full record

ArticleFrontiers in pharmacology2022

Application of an Accessible Interface for Pharmacokinetic Modeling and

David E Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen, Nicole Kleinstreuer

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Re-Thinking Pharmacokinetics in Ovarian Cancer: What Do Organoids Add?International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David E HinesInotiv-RTP, Research Triangle Park, Durham, NC, United States.
Shannon BellInotiv-RTP, Research Triangle Park, Durham, NC, United States.
Xiaoqing ChangInotiv-RTP, Research Triangle Park, Durham, NC, United States.
Kamel MansouriNIH/NIEHS/DNTP/NICEATM, Research Triangle Park, Durham, NC, United States.
David AllenInotiv-RTP, Research Triangle Park, Durham, NC, United States.
Nicole KleinstreuerNIH/NIEHS/DNTP/NICEATM, Research Triangle Park, Durham, NC, United States.

Funding

Scientific Cyberinfrastructure Research ProgramZIAES103385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, VICKIE · 2022 to 2025
$17.4M
Research Operations Supporting the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological MethodsZICES103386 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HOGBERG-DURDOCK, HELENA · 2022 to 2025
$3.3M
6 · The paper itself

Abstract

Regulatory toxicology testing has traditionally relied on

Indexed as

computational modeling methodshazard screeningin vitro to in vivo extrapolationnew approach methodologyphysiologically–based pharmacokinetic modelrisk assessment

Identifiers

PMID35496281
PMCPMC9043603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.