Evidence map›Paper›PMID 35496263›Full record

ArticleAdvances in radiation oncology

Gadoxetic Acid Uptake Rate as a Measure of Global and Regional Liver Function as Compared With Indocyanine Green Retention, Albumin-Bilirubin Score, and Portal Venous Perfusion.

Josiah Simeth, Madhava Aryal, Dawn Owen, Kyle Cuneo, Theodore S Lawrence, Yue Cao

Open access · goldAbstract read
In one paragraph

Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. PET/CT-Based Absorbed Dose Maps inJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Josiah SimethDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Madhava AryalDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Dawn OwenDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN.
Kyle CuneoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Theodore S LawrenceDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Yue CaoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI.
University of Michigan · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
TREATMENT VERIFICATION AND TREATMENT PLAN REFINEMENTP01CA059827 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KESSLER, MARC LEWIS, LAWRENCE, THEODORE S · 1993 to 2018
$37.9M
Predicting Liver Function After IrradiationR01CA132834 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAO, YUE · 2010 to 2015
$1.7M
NCI NIH HHS P01 CA059827NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA132834
6 · The paper itself

Abstract

Purpose: Global and regional liver function assessments are important for defining the magnitude and spatial distribution of dose to preserve functional liver parenchyma and reduce incidence of hepatotoxicity from radiation therapy for intrahepatic cancer treatment. This individualized liver function-guided radiation therapy strategy is critical for patients with heterogeneous and poor liver function, often observed in cirrhotic patients treated for hepatocellular carcinoma. This study aimed to validate Methods and Materials: Seventy-nine dynamic gadoxetic acid enhanced magnetic resonance imaging scans were acquired in 40 patients with hepatocellular carcinoma in institutional review board approved prospective protocols. Portal venous perfusion ( Results: Significant correlations ( Conclusions: The metric combining function and liver volume (

Identifiers

PMID35496263
PMCPMC9048078
OpenAlexW4220891868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.