Evidence map›Paper›PMID 35495915›Full record

ReviewFrontiers in nutrition2022

Molecular Mechanisms of Iron Mediated Programmed Cell Death and Its Roles in Eye Diseases.

Jie Zhang, Shuai Sheng, Wenting Wang, Jiazhen Dai, Yifan Zhong, Jiantao Ren, Keke Jiang, Shuchan Li, Xiaoyan Bian, Lei Liu

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie ZhangDepartment of Public Health, Weifang Medical University, Weifang, China.
Shuai ShengDepartment of Ophthalmology, Weifang Eye Hospital, Weifang, China.
Wenting WangDepartment of Ophthalmology, Weifang Eye Hospital, Weifang, China.
Jiazhen DaiDepartment of Ophthalmology, Weifang Eye Hospital, Weifang, China.
Yifan ZhongDepartment of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Jiantao RenDepartment of Ophthalmology, Weifang Eye Hospital, Weifang, China.
Keke JiangDepartment of Ophthalmology, Weifang Eye Hospital, Weifang, China.
Shuchan LiDepartment of Ophthalmology, Weifang Eye Hospital, Weifang, China.
Xiaoyan BianDepartment of Ocular Surface, Baotou Chaoju Eye Hospital, Boatou, China.
Lei LiuDepartment of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Eye Institute, Guangdong Academy of Medical Sciences, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis, a newly identified, iron-dependent type of programmed cell death, is active in several diseases, such as heart disease, brain damage, and cancer. Its main characteristics commonly involve excess iron accumulation, elevated lipid peroxides and reactive oxygen species, and reduced levels of glutathione and glutathione peroxidase 4 levels. The effects of ferroptosis in eye diseases cannot be underestimated, with ferroptosis becoming a research target in ocular disorders and emerging evidence from a series of

Indexed as

cell deatheye diseasesferroptosisironlipid peroxidation

Identifiers

PMID35495915
PMCPMC9038536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.