ArticleFrontiers in microbiology2022
Multi-Omics Reveals That the Rumen Transcriptome, Microbiome, and Its Metabolome Co-regulate Cold Season Adaptability of Tibetan Sheep.
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 46 citations in OpenAlex.
- Rumen Microbiota, Predicted Metabolic Pathways, and Fermentation Parameters Exhibit Production-System-Specific Associations in Cattle and Goats.Microorganisms · 2026Article
- Rumen epithelial functional adaptation in alpine ewes: transcriptomic effects of micronutrient premix and concentrate supplementation levels.Stress biology · 2026Article
- Integrated mRNA-miRNA Transcriptome Analysis Reveals the Molecular Mechanism of Tibetan Sheep Rumen Epithelium Adaptation to High Altitude.Animals : an open access journal from MDPI · 2026Article
- The Dairy Ruminant Gut Microbiome: Profile, Responsiveness to Seasonality and Impact on Milk Quality.Environmental microbiology · 2026Review
- Host-microbiome interplay supports heat stress resilience in zebu calves.Animal microbiome · 2026Article
- Article
- Copper-molybdenum interactions in ruminant nutrition and reproductive physiology: mechanistic insights into growth, digestibility, and follicular development.Frontiers in veterinary science · 2026Review
- Multi-Omics Analysis Reveals Concentrate Supplementation Alleviates Body Weight Loss by Regulating Rumen Function in Lactating Tibetan Sheep During the Cold Season.Animals : an open access journal from MDPI · 2025Article
- Effects of Diets with Different Energy Levels at Cold Temperatures on Gut Microbiota and Metabolic State in Growing-Finishing Pigs.Microorganisms · 2025Article
- Analysis of Population Structure and Selection Signatures in Two Iraqi Fat-Tailed Sheep Breeds.Veterinary medicine and science · 2025Article
- Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep.Microbiome · 2025Article
- Gut Microbiota of Ruminants and Monogastric Livestock: An Overview.Animals : an open access journal from MDPI · 2025Review
- Effects of Yeast Culture on Lamb Growth Performance, Rumen Microbiota, and Metabolites.Animals : an open access journal from MDPI · 2025Article
- Impact of Lysine to Methionine Ratios on Antioxidant Capacity and Immune Function in the Rumen of Tibetan Sheep: An RNA-Seq Analysis.Veterinary medicine and science · 2025Article
- Triadic relationships between pasture exposure, gastrointestinal parasites, and hindgut microbiomes in grazing lambs.PloS one · 2025Article
- Comparative analysis of cecal microbiota and metabolites in relation to growth performance of Tibetan and Hu sheep.Frontiers in microbiology · 2025Article
- Multi-Omics Approaches Uncovered Critical mRNA-miRNA-lncRNA Networks Regulating Multiple Birth Traits in Goat Ovaries.International journal of molecular sciences · 2024Article
- Environmental Driving of Adaptation Mechanism on Rumen Microorganisms of Sheep Based on Metagenomics and Metabolomics Data Analysis.International journal of molecular sciences · 2024Article
- Comparative Analysis of the Potential Adaptability of Tibetan Dzo and Yellow Cattle Based on Blood Indices, Metabolites, and Fecal Microbiota.Animals : an open access journal from MDPI · 2024Article
- Microbial Community Structure and Metabolism of Xinjiang Fine-Wool Sheep based on High-Throughput Sequencing Technology.Current microbiology · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
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Abstract
Tibetan sheep can maintain a normal life and reproduce in harsh environments under extreme cold and lack of nutrition. However, the molecular and metabolic mechanisms underlying the adaptability of Tibetan sheep during the cold season are still unclear. Hence, we conducted a comprehensive analysis of rumen epithelial morphology, epithelial transcriptomics, microbiology and metabolomics in a Tibetan sheep model. The results showed that morphological structure of rumen epithelium of Tibetan sheep in cold season had adaptive changes. Transcriptomics analysis showed that the differential genes were primarily enriched in the PPAR signaling pathway (ko03320), legionellosis (ko05134), phagosome (ko04145), arginine and proline metabolism (ko00330), and metabolism of xenobiotics by cytochrome P450 (ko00980). Unique differential metabolites were identified in cold season, such as cynaroside A, sanguisorbin B and tryptophyl-valine, which were mainly enriched in arachidonic acid metabolism, arachidonic acid metabolism and linolenic acid metabolism pathways, and had certain correlation with microorganisms. Integrated transcriptome-metabolome-microbiome analysis showed that epithelial gene-
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