ArticleInfection and immunity1987
Killing of Plasmodium falciparum by eosinophil secretory products.
Article in Infection and immunity, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Ribonucleases of Mice and Men: Unveiling the Roles of the RNase A Superfamily in Host Defence.Journal of immunology research · 2025Review
- Exposure to common infections may shape basal immunity and potentially HIV-1 acquisition amongst a high-risk population in Coastal Kenya.Frontiers in immunology · 2023Article
- Trichinella spiralis co-infection exacerbates Plasmodium berghei malaria-induced hepatopathy.Parasites & vectors · 2020Article
- Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.Malaria journal · 2018Article
- Immune Modulation by Human Secreted RNases at the Extracellular Space.Frontiers in immunology · 2018Review
- Parasite and the Circulating Pool- Characterisation of Leukocyte Number and Morphology in Malaria.Journal of clinical and diagnostic research : JCDR · 2016Article
- Eosinophils in mucosal immune responses.Mucosal immunology · 2015Review
- IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.PLoS pathogens · 2015Article
- Molecular analysis of non-specific protection against murine malaria induced by BCG vaccination.PloS one · 2013Article
- Peroxisome proliferator activating receptor (PPAR) in cerebral malaria (CM): a novel target for an additional therapy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Review
- Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.PloS one · 2011Article
- The RNase a superfamily: generation of diversity and innate host defense.Molecular diversity · 2006Review
- Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
- Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Increased eosinophil activity in acute Plasmodium falciparum infection--association with cerebral malaria.Clinical and experimental immunology · 1998Article
- Characterization of liver lymphomyeloid cells in mice infected with Plasmodium yoelii sporozoites.Immunology · 1994Article
- Status of malaria vaccine research.Journal of the Royal Society of Medicine · 1989Review
- Killing of blood-stage Plasmodium falciparum by lipid peroxides from tumor necrosis serum.Infection and immunity · 1988Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multiplication of two strains of Plasmodium falciparum in culture, as measured by [3H]hypoxanthine incorporation, was inhibited in a dose-dependent manner by granule proteins secreted by purified eosinophils obtained from patients with the hypereosinophilic syndrome. Morphological examination revealed the presence of abnormal parasites inside erythrocytes, indicating that they were killed in situ, and the later stages of the developmental cycle were found to be most susceptible to these toxic effects. A monoclonal antibody against eosinophil cationic protein partially blocked the inhibitory effect, suggesting that it was caused by more than one of the eosinophil granule proteins. Thus some of the antimalarial effects of molecules such as the tumor necrosis factor, which activates eosinophils, may be mediated through the enhanced production of eosinophil secretion products.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.