Evidence map›Paper›PMID 35495619›Full record

ReviewFrontiers in molecular biosciences2022

Multisystem Inflammatory Syndrome and Autoimmune Diseases Following COVID-19: Molecular Mechanisms and Therapeutic Opportunities.

Parastoo Hosseini, Mohammad Sadegh Fallahi, Gisou Erabi, Majid Pakdin, Seyed Mahdi Zarezadeh, Arezoo Faridzadeh, Sarina Entezari, Arina Ansari, Mohadeseh Poudineh, Niloofar Deravi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Parastoo HosseiniDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Sadegh FallahiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Gisou ErabiStudent Research Committee, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Majid PakdinStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mahdi ZarezadehSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Arezoo FaridzadehDepartment of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sarina EntezariStudent Research Committee, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arina AnsariStudent Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Mohadeseh PoudinehSchool of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Niloofar DeraviStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRMashhad University of Medical Sciences · IRNorth Khorasan University of Medical Sciences · IRShiraz University of Medical Sciences · IRUrmia University of Medical SciencesZanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has led to huge concern worldwide. Some SARS-CoV-2 infected patients may experience post-COVID-19 complications such as multisystem inflammatory syndrome, defined by symptoms including fever and elevated inflammatory markers (such as elevation of C reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, procalcitonin test, D-dimer, ferritin, lactate dehydrogenase or IL-6, presence of neutrophilia, lymphopenia, decreased albumin, and multiple organ dysfunction). Post-COVID-19 complications may also manifest as autoimmune diseases such as Guillain-Barré syndrome and systemic lupus erythematosus. Signaling disorders, increased inflammatory cytokines secretion, corticosteroid use to treat COVID-19 patients, or impaired immune responses are suggested causes of autoimmune diseases in these patients. In this review, we discuss the molecular and pathophysiological mechanisms and therapeutic opportunities for multisystem inflammatory syndrome and autoimmune diseases following SARS-CoV-2 infection with the aim to provide a clear view for health care providers and researchers.

Indexed as

autoimmune diseaseCOVID-19multisystem inflammatory syndromemultisystem inflammatory syndrome in children (MIS-C)SARS-CoV2

Identifiers

PMID35495619
PMCPMC9046575
OpenAlexW4223982366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.