Evidence map›Paper›PMID 35495617›Full record

ReviewTherapeutic advances in ophthalmology

Ocular adverse effects of therapeutic biologics.

Helio V Neves da Silva, John Placide, Anne Duong, Yasmyne Ronquillo, Shannon McCabe, Majid Moshirfar

Open access · diamondAbstract readReview
In one paragraph

Review in Therapeutic advances in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. A rare encounter:IDCases · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Helio V Neves da SilvaUniversity of Colorado School of Medicine, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-8572-9946
John PlacideMcGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
Anne DuongMcGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
Yasmyne RonquilloHoopes Vision Research Center, Draper, UT, USA.ORCID https://orcid.org/0000-0002-8852-4380
Shannon McCabeHoopes Vision Research Center, Draper, UT, USA.
Majid MoshirfarHoopes Research Center, 11820 South State Street, Suite 200, Draper, UT 84020, USA.ORCID https://orcid.org/0000-0003-1024-6250
Hoopes Vision · USThe University of Texas Health Science Center at Houston · USState Street (United States) · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological drugs, termed biologics, are medications that contain or are derived from a living organism (human, animal, or microorganism). With new biological agents being approved by the Food and Drug Administration (FDA) every year, clinicians need to know potential ocular adverse effects that are associated with these drugs. This review provides an overview of ocular adverse effects of biological medications used to treat both ophthalmic and non-ophthalmic diseases. We searched PubMed for relevant case reports, case series, reviews, and clinical trials reporting ocular adverse effects caused by biologics. This review was conducted in June 2021 and investigated the drugs listed in the most updated (April 2021) FDA Purple Book Database of Licensed Biological Products. This review focuses on monoclonal antibodies, interleukins, and receptor fusion proteins. We explore ocular side effects of 33 biological drugs, stating whether they are frequent, common, or rare.

Indexed as

biological medicationsbiologicsocular adverse effectsocular side effectsocular toxicityophthalmic side effects

Identifiers

PMID35495617
PMCPMC9047051
OpenAlexW4225326955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.