ArticleRSC advances2020
Effects of cholesterol on bilayers with various degrees of unsaturation of their phospholipid tails under mechanical stress.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparing multislice projections of MD simulations with cryo-EM exposes structural prediction errors.Biophysical journal · 2026Article
- Edible Fungal Polysaccharide-Liposome: Interfacial Interactions, Structure-Function Relationship, and Emerging Application in Oral Delivery and Functional Foods.International journal of molecular sciences · 2026Review
- Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2.Protein science : a publication of the Protein Society · 2026Article
- Extrahepatic Gene Editing In Vivo Using Organic Solvent-Free Lipid Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Comparing Multislice Projections of MD Simulations with CryoEM Exposes Structural Prediction Errors.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol is one of the essential components of the cell membrane. It has a significant influence on various mechanical properties of biomembranes, such as fluidity and elasticity, which have attracted much attention. It is also well known that the concentration of cholesterol affects the mechanical strength of cell membranes. In this paper, we aim to explore the influence of the degree of unsaturation of phospholipid tails on the concentration-effect of cholesterol. Three different phospholipids (DPPC, DIPC and DAPC) were selected as the respective main components of the bilayers and several concentrations of cholesterol were also added to the systems. Our coarse-grained molecular dynamics simulations show that as the cholesterol concentration increases, the saturated phospholipid bilayer is first strengthened, by increasing the rupture tension from 68.9 to 110 mN m
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Registered trials
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