Evidence map›Paper›PMID 35495121›Full record

ArticleFrontiers in genetics2022

A Sequence Obfuscation Method for Protecting Personal Genomic Privacy.

Shibiao Wan, Jieqiong Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Methods for safely sharing dual-use genetic data.Frontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Shibiao WanCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, United States.
Jieqiong WangDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
St. Jude Children's Research Hospital · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the technological advances in recent decades, determining whole genome sequencing of a person has become feasible and affordable. As a result, large-scale individual genomic sequences are produced and collected for genetic medical diagnoses and cancer drug discovery, which, however, simultaneously poses serious challenges to the protection of personal genomic privacy. It is highly urgent to develop methods which make the personal genomic data both utilizable and confidential. Existing genomic privacy-protection methods are either time-consuming for encryption or with low accuracy of data recovery. To tackle these problems, this paper proposes a sequence similarity-based obfuscation method, namely IterMegaBLAST, for fast and reliable protection of personal genomic privacy. Specifically, given a randomly selected sequence from a dataset of genomic sequences, we first use MegaBLAST to find its most similar sequence from the dataset. These two aligned sequences form a cluster, for which an obfuscated sequence was generated

Indexed as

clusteringDNA generalization latticegenomic privacyIterMegaBLASTmachine learningMegaBLASTobfuscation methodssequence similarity

Identifiers

PMID35495121
PMCPMC9043694
OpenAlexW4224119326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.