ReviewCureus2022
Elevated Serum Uric Acid and Cardiovascular Disease: A Review and Potential Therapeutic Interventions.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Impact of gout on cardiovascular disease mortality: a meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
- The association between uric acid and incident cardiovascular events amongst healthy, community-dwelling older adults.GeroScience · 2026Article
- Antibacterial, antioxidant, and xanthine-oxidase inhibitory screening studies of selected cyperaceae species occurring in Europe.Biologia futura · 2026Article
- Predicting short-term composite outcome risk in heart failure patients using a machine learning model incorporating UHR: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Higher serum uric acid levels are associated with an increased risk of carotid atherosclerosis in 67,256 adults.Frontiers in nutrition · 2026Article
- The impact of uric acid on acute coronary syndrome prognosis in elderly patients.Annals of medicine · 2025Article
- Integrating Renal and Metabolic Parameters into a Derived Risk Score for Hyperuricemia in Uncontrolled Type 2 Diabetes: A Retrospective Cross-Sectional Study in Northwest Romania.Medicina (Kaunas, Lithuania) · 2025Article
- Eco-friendly synthesis of carbon quantum dots from lemons for enhanced uric acid detection using gold-integrated surface plasmon resonance.Scientific reports · 2025Article
- URAT1 and GLUT9 as drug targets in gout: progress in transporter-directed therapies and delivery technologies.Inflammopharmacology · 2025Review
- Association between coronary monosodium urate deposits at DECT and high-risk coronary plaque phenotypes and other features in gout patients.European radiology experimental · 2025Article
- Characteristics and Management of Uncontrolled Gout Prior to Pegloticase Therapy: A 2-year Claims Analysis.Rheumatology and therapy · 2025Article
- Hyperuricemia Is Associated With Higher Mortality in Non-diabetic Heart Failure Patients.Cureus · 2024Article
- Association of serum uric acid to all-cause and cardiovascular mortality in patients with cardiovascular disease.Scientific reports · 2024Article
- Prognostic Significance of Serum Uric Acid and Exercise Capacity in Older Adults Hospitalized for Worsening Cardiovascular Disease.Journal of cardiovascular development and disease · 2024Article
- Correlation between SUA and prognosis in CHF patients after revascularization.Journal of medical biochemistry · 2024Article
- Role of Uric Acid in Vascular Remodeling: Cytoskeleton Changes and Migration in VSMCs.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several landmark studies found a relationship between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD). In fact, the association between hyperuricemia and hypertension (HTN), coronary artery disease (CAD), and heart failure (HF) is currently well-established. While the mechanism linking hyperuricemia and CVD is not fully known, a systemic inflammatory response by the host is believed to play a role. With the goal of decreasing the morbidity and mortality of CVD in patients with hyperuricemia, the focus has now turned to properly optimizing a medication regimen for this patient population. Recent studies have shown that controlling underlying inflammation can, in fact, lead to better cardiovascular outcomes for populations with acute and chronic coronary disease. In this paper, we will discuss the current state of understanding on the association of hyperuricemia and cardiovascular disease. Furthermore, we will look into the most recent clinical trials showing the effects anti-inflammatory medications have on both decreasing and recovering from cardiovascular events. We will conclude with a discussion on, given the information mentioned above, how to properly optimize a medication regimen in patients with elevated SUA levels with a focus on decreasing the morbidity and mortality associated with CVD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.