Evidence map›Paper›PMID 35494965›Full record

ArticleCureus2022

An Unusual Cause of Refractory Hypothyroidism.

Omead J Mirgoli, Vishal Ramjas, Samhitha Munugoti, Heather Silverstein, Fawad Malik, Ahmed Salem, Frank Cassavell, Adam Atoot

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Association betweenFrontiers in endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Omead J MirgoliFamily Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.
Vishal RamjasMedicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Samhitha MunugotiInternal Medicine, Prime Health Care Consortium at St. Mary's and St. Clare Denville Hospital Program, Denville, USA.
Heather SilversteinInternal Medicine, Nova Southeastern University Dr. Kiran C. Patel College Of Osteopathic Medicine, Fort Lauderdale, USA.
Fawad MalikPharmacy, Bellevue Hospital, New York City, USA.
Ahmed SalemInternal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.
Frank CassavellInternal Medicine, Hackensack Meridian School of Medicine, Nutley, USA.
Adam AtootInternal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.
Denso (United States) · USBellevue Hospital Center · USCalifornia Institute of Behavioral Neurosciences and Psychology (United States) · USCenter for Discovery · USHackensack Meridian Health · USNova Southeastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Refractory hypothyroidism has been increasingly identified worldwide. Primary hypothyroidism is considered refractory when there is a persistent elevation of thyroid-stimulating hormone (TSH) above the upper limit of normal despite escalating doses of levothyroxine with or without the persistence of hypothyroid symptoms. Further escalation of levothyroxine to supratherapeutic doses could be associated with potential complications such as iatrogenic hyperthyroidism, cardiac failure, and other conditions. Therefore, physicians should rule out non-compliance and pursue a further evaluation to identify etiologies for increased requirements or decreased absorption of levothyroxine in patients not achieving therapeutic doses. Here, we present a 40-year-old Indian male with worsening refractory hypothyroidism that resolved following eradication of his

Indexed as

h pylori infectionlevothyroxinemalabsorptionrefractory hypothyroidismthyroid-stimulating hormone (tsh)

Identifiers

PMID35494965
PMCPMC9038596
OpenAlexW4220728434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.