Evidence map›Paper›PMID 35494963›Full record

ArticleCureus2022

Diabetic Ketoacidosis With Refractory Hypokalemia Leading to Cardiac Arrest.

Sarah Grout, Danielle Maue, Zachary Berrens, Nathan Swinger, Stefan Malin

Abstract readCase Reports
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah GroutDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.
Danielle MaueDepartment of Pediatrics, Division of Critical Care, Riley Hospital for Children, Indianapolis, USA.
Zachary BerrensDepartment of Pediatrics, Division of Critical Care, Riley Hospital for Children, Indianapolis, USA.
Nathan SwingerDepartment of Pediatrics, Division of Critical Care, Riley Hospital for Children, Indianapolis, USA.
Stefan MalinDepartment of Pediatrics, Division of Critical Care, Indiana University School of Medicine, Indianapolis, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic ketoacidosis (DKA) is known to cause total body potassium depletion, but during initial presentation, very few patients are hypokalemic, and even fewer patients experience clinical effects. As the correction of acidosis and insulin drive potassium intracellularly, measured serum potassium levels decrease and require repletion. This phenomenon is well described, and severe hypokalemia necessitates delaying insulin therapy. Less well described is the kaliuretic nature of treatments of cerebral edema. We present a case of an adolescent male with new-onset type 2 diabetes who presented in DKA with signs of cerebral edema, hyperosmolarity, and hypokalemia. As insulin and cerebral edema therapy were initiated, his hypokalemia worsened despite significant IV repletion, eventually leading to ventricular tachycardia and cardiac arrest. Over the following 36 hours, the patient received >590 milliequivalents (mEq) of potassium. He was discharged home 12 days after admission without sequelae of his cardiac arrest.

Indexed as

cardiac arrhythmiadiabetic ketoacidosis (dka)electrolyte disturbancesglobal cerebral edemaventricular tachycardia (vt)

Identifiers

PMID35494963
PMCPMC9038207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.