Evidence map›Paper›PMID 35494740›Full record

ArticleRSC advances2021

Utilizing polymer-conjugate albumin-based ultrafine gas bubbles in combination with ultra-high frequency radiations in drug transportation and delivery.

Thi H Le, An H T Phan, Khoa C M Le, Thy D U Phan, Khoi T Nguyen

Abstract read
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thi H LeSchool of Biotechnology, International University, Vietnam National University Ho Chi Minh City Vietnam +84(8)3724 4271 +84(8)3724 4270.
An H T PhanSchool of Biotechnology, International University, Vietnam National University Ho Chi Minh City Vietnam +84(8)3724 4271 +84(8)3724 4270.
Khoa C M LeSchool of Biotechnology, International University, Vietnam National University Ho Chi Minh City Vietnam +84(8)3724 4271 +84(8)3724 4270.
Thy D U PhanSchool of Biotechnology, International University, Vietnam National University Ho Chi Minh City Vietnam +84(8)3724 4271 +84(8)3724 4270.
Khoi T NguyenSchool of Biotechnology, International University, Vietnam National University Ho Chi Minh City Vietnam +84(8)3724 4271 +84(8)3724 4270.ORCID https://orcid.org/0000-0003-3934-0371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of ultrafine bubbles as drug carriers in drug delivery is still in its developmental stage; it is important to obtain a thorough understanding of the factors affecting the formation and stability of drug carrier matrices. In this study, the polyethylene glycol (PEG)-conjugated human serum albumin (HSA)-based ultrafine bubble simulating the physiological electrolyte concentration in human blood (154 mM) for quercetin delivery was investigated. Optical absorbance measurements, surface tension measurements, and fluorescence laser imaging were also employed to assess the plausibility of polymer-conjugated albumin-stabilized ultrafine bubbles in drug loading and drug release. The incorporation of PEG/HSA into the system illustrated a significant enhancement in the matrix's stability as confirmed by surface tension measurements and drug-loading efficiency achieving approximately 90%. In addition,

Identifiers

PMID35494740
PMCPMC9042728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.