Evidence map›Paper›PMID 35494480›Full record

ArticleAdvanced therapeutics2019

Indocyanine Green-Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy.

Elizabeth Higbee-Dempsey, Ahmad Amirshaghaghi, Matthew J Case, Joann Miller, Theresa M Busch, Andrew Tsourkas

Open access · greenAbstract read
In one paragraph

Article in Advanced therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 46 citations in OpenAlex.

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  13. Active Micro/Nanoparticles in Colloidal Microswarms.Nanomaterials (Basel, Switzerland) · 2023
    Review
  14. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elizabeth Higbee-DempseyBiochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ahmad AmirshaghaghiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew J CaseCollege of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Joann MillerDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Theresa M BuschDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · USMedical University of South Carolina · US

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
SUMMER UNDERGRADUATE PROGRAM TO EDUCATE RADIATION SCIENTISTS (SUPERS)R25CA140116 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JAY FITZGERALD DORSEY · 2010 to 2026
$4.1M
Radiation and Receptor Targeted RadioTheranostic Nanoparticles for GlioblastomaR01CA181429 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DORSEY, JAY FITZGERALD · 2014 to 2018
$2.4M
Photodynamic therapy with prior inhibition of epidermal growth factor receptor to stimulate antitumor innate immune responseR01CA236362 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M · 2019 to 2023
$2.2M
NCI NIH HHS P01 CA087971NCI NIH HHS R01 CA181429NCI NIH HHS R01 CA236362NCI NIH HHS R25 CA140116
6 · The paper itself

Abstract

Traditional oncology treatment modalities are often associated with a poor therapeutic index. This has driven the development of new targeted treatment modalities, including several based on the conversion of optical light into heat energy (photothermal therapy, PTT) and sound waves (photoacoustic imaging, PA) that can be applied locally. These approaches are especially effective when combined with photoactive nanoparticles that preferentially accumulate in tissues of interest and thereby further increase spatiotemporal resolution. In this study, two clinically-used materials that have proven effective in both PTT and PA - indocyanine green and gold nanoparticles - were combined into a single nanoformulation. These particles, "ICG-AuNP clusters", incorporated high concentrations of both moieties without the need for additional stabilizing or solubilizing reagents. The clusters demonstrated high theranostic efficacy both

Indexed as

gold nanoparticlesindocyanine greenphotoacoustic imagingphotothermal therapytheranostic

Identifiers

PMID35494480
PMCPMC9052658
OpenAlexW2964835107

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.