Evidence map›Paper›PMID 35494427›Full record

ArticleRSC advances2020

Biocompatible supramolecular pseudorotaxane hydrogels for controllable release of doxorubicin in ovarian cancer SKOV-3 cells.

Caixia Li, Hanxue Li, Jiahao Guo, Liang Li, Xiaowei Xi, Yanyan Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caixia LiShanghai General Hospital of Nanjing Medical University 100 Haining Road, Hongkou District Shanghai 200080 P.R. China xiaoweixi19@126.com.
Hanxue LiSchool of Chemical and Environmental Engineering of Shanghai Institute of Technology 100 Haiquan Road Shanghai 201418 P.R. China sshnhyyy@sit.edu.cn.
Jiahao GuoSchool of Chemical and Environmental Engineering of Shanghai Institute of Technology 100 Haiquan Road Shanghai 201418 P.R. China sshnhyyy@sit.edu.cn.
Liang LiSchool of Chemical and Environmental Engineering of Shanghai Institute of Technology 100 Haiquan Road Shanghai 201418 P.R. China sshnhyyy@sit.edu.cn.
Xiaowei XiShanghai General Hospital of Nanjing Medical University 100 Haining Road, Hongkou District Shanghai 200080 P.R. China xiaoweixi19@126.com.ORCID https://orcid.org/0000-0002-6210-8696
Yanyan YuSchool of Chemical and Environmental Engineering of Shanghai Institute of Technology 100 Haiquan Road Shanghai 201418 P.R. China sshnhyyy@sit.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of injectable and biocompatible delivery DOX-loaded supramolecular hydrogels were fabricated by using presynthesized DOX-2N-β-CD, Pluronic F-127 and α-CD through host-guest interactions and cooperative multivalent hydrogen bonding interactions. The compositions and morphologies of these hydrogels were confirmed by PXRD and SEM measurements. Moreover, the Rheological measurements of these hydrogels were studied and the studies found that they showed a unique thixotropic behavior, indicting a fast self-healing property after the continuous oscillatory shear stress. Using α-CD as a capping agent, slow and sustained DOX release was observed at different pH values after 72 h. The amount of DOX released at pH 7.4 was determined to be 49.0% for hydrogel 1, whereas the releasing amount of the DOX was increased to 66.3% for hydrogel 1 during the same period at pH 5.5 (

Identifiers

PMID35494427
PMCPMC9048191

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.