ArticleAdvances in optics and photonics2021
Spatial light interference microscopy: principle and applications to biomedicine.
Article in Advances in optics and photonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Brain-SAM: a general automatic SAM-based segmentation model for brain science images.Biomedical optics express · 2026Article
- Scattering-enabled epi-quantitative phase imaging reveals subcellular detail in organoids and deep mouse brains.bioRxiv : the preprint server for biology · 2026Article
- Impact of uniform illumination in widefield microscopy and mesoscopy.Scientific reports · 2025Article
- Dual Photonics Probing of Nano- to Submicron-Scale Structural Alterations in Human Brain Tissues/Cells and Chromatin/DNA with the Progression of Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Quantitative phase imaging endoscopy with a metalens.Light, science & applications · 2024Article
- Quantitative phase microscopies: accuracy comparison.Light, science & applications · 2024Review
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.Journal of biomedical optics · 2024Review
- Vibrational imaging of metabolites for improved microbial cell strains.Journal of biomedical optics · 2024Review
- Multispectral Holographic Intensity and Phase Imaging of Semitransparent Ultrathin Films.ACS photonics · 2024Article
- Article
- Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Quantitative Measurements of Red Blood Cell Indices Using Spectroscopic Differential Phase-Contrast Microscopy.Chemical & biomedical imaging · 2023Article
- Polarization differential interference contrast microscopy with physics-inspired plug-and-play denoiser for single-shot high-performance quantitative phase imaging.Biomedical optics express · 2023Article
- Panoramic quantitative phase imaging of adherent live cells in a microfluidic environment.Biomedical optics express · 2023Article
- Artificial confocal microscopy for deep label-free imaging.Nature photonics · 2023Article
- Bond-selective intensity diffraction tomography.Nature communications · 2022Article
- Digital Histopathological Discrimination of Label-Free Tumoral Tissues by Artificial Intelligence Phase-Imaging Microscopy.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting interferometer, built onto a phase-contrast microscope, with white-light illumination. As one of the most sensitive quantitative phase imaging (QPI) methods, SLIM allows for speckle-free phase reconstruction with sub-nanometer path-length stability. We first review image formation in QPI, scattering, and full-field methods. Then, we outline SLIM imaging from theory and instrumentation to diffraction tomography. Zernike's phase-contrast microscopy, phase retrieval in SLIM, and halo removal algorithms are discussed. Next, we discuss the requirements for operation, with a focus on software developed in-house for SLIM that enables high-throughput acquisition, whole slide scanning, mosaic tile registration, and imaging with a color camera. We introduce two methods for solving the inverse problem using SLIM, white-light tomography, and Wolf phase tomography. Lastly, we review the applications of SLIM in basic science and clinical studies. SLIM can study cell dynamics, cell growth and proliferation, cell migration, mass transport, etc. In clinical settings, SLIM can assist with cancer studies, reproductive technology, blood testing, etc. Finally, we review an emerging trend, where SLIM imaging in conjunction with artificial intelligence brings computational specificity and, in turn, offers new solutions to outstanding challenges in cell biology and pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.