ArticleRSC advances2021
A sandwich SERS immunoassay platform based on a single-layer Au-Ag nanobox array substrate for simultaneous detection of SCCA and survivin in serum of patients with cervical lesions.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Nanotechnology and nanobots unleashed: pioneering a new era in gynecological cancer management - a comprehensive review.Cancer chemotherapy and pharmacology · 2025Review
- Comparison of Survivin Determination by Surface-Enhanced Fluorescence and Raman Spectroscopy on Nanostructured Silver Substrates.Biosensors · 2024Article
- The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine.Chemical reviews · 2023Review
- SERS Immunosensors for Cancer Markers Detection.Materials (Basel, Switzerland) · 2023Review
- Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women's Health Issue-A Review.Molecules (Basel, Switzerland) · 2023Review
- Recent Advances in Sandwich SERS Immunosensors for Cancer Detection.International journal of molecular sciences · 2022Review
- Development and Validation of a Raman Spectroscopic Classification Model for Cervical Intraepithelial Neoplasia (CIN).Cancers · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evaluation of tumor biomarkers in blood specimens is vital for patients with cervical lesions. Herein, an ultrasensitive surface enhanced Raman scattering (SERS) platform was proposed for simultaneous detection of cervical-lesion-related serum biomarkers. Raman reporter labeled Au-Ag nanoshells (Au-AgNSs) acted as SERS tags and an Au-Ag nanobox (Au-AgNB) array substrate prepared by the oil-water interface self-assembly method was used as a capture substrate. This single-layer Au-AgNB array substrate was proved to have exceptional uniformity by atomic force microscopy and SERS mapping. Numerous "hot spots" and specific adsorption surfaces offered by the Au-AgNB array substrate were confirmed by the finite difference time domain method, which could generate a SERS signal in electromagnetic enhancement. Binding of antigens between antibodies on Au-AgNSs and the Au-AgNB array substrate led to the formation of a sandwich-structure by the two metal nanostructures. Consequently, an ultralow detection limit of 6 pg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.