Evidence map›Paper›PMID 35494243›Full record

ArticleiScience2022

Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis.

Suresh Chava, Suresh Bugide, Xuchen Zhang, Romi Gupta, Narendra Wajapeyee

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Elucidation of Factors Affecting the Age-Dependent Cancer Occurrence Rates.International journal of molecular sciences · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Suresh ChavaDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Suresh BugideDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Xuchen ZhangDepartment of Pathology, Yale University, New Haven, CT 06510, USA.
Romi GuptaDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Narendra WajapeyeeDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
University of Alabama at Birmingham · USYale University · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
A Novel Druggable Epigenetic Vulnerability Pathway in HCCR01CA218008 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KELLIHER, MICHELLE ALICE, WAJAPEYEE, NARENDRA · 2018 to 2022
$2.9M
A NOVEL DRUGGABLE GENETIC VULNERABILITY PATHWAY IN MELANOMAR01CA200919 · NCI · YALE UNIVERSITY · PI WAJAPEYEE, NARENDRA · 2016 to 2020
$1.8M
PRECISION METABOLIC THERAPY OF p53 MUTANT TRIPLE NEGATIVE BREAST CANCERSR01CA233481 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUPTA, ROMI · 2021 to 2025
$1.6M
ANOIKIS EFFECTORS AS DRIVERS OF METASTATIC MELANOMAR21CA195077 · NCI · YALE UNIVERSITY · PI WAJAPEYEE, NARENDRA · 2016 to 2016
$218k
A NOVEL EPIGENETIC IMMUNOTHERAPY FOR OVARIAN CANCER TREATMENTR03CA230815 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUPTA, ROMI · 2019 to 2020
$149k
A Novel Anoikis Effector that Drives Ovarian Cancer MetastasisR03CA248913 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUPTA, ROMI · 2020 to 2021
$149k
NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA200919NCI NIH HHS R01 CA218008NCI NIH HHS R01 CA233481NCI NIH HHS R03 CA230815NCI NIH HHS R03 CA248913NCI NIH HHS R21 CA195077
6 · The paper itself

Abstract

Oncogenic mutations in the

Indexed as

CancerCell biologyTranscriptomics

Identifiers

PMID35494243
PMCPMC9048069
OpenAlexW4224282314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.