Evidence map›Paper›PMID 35494229›Full record

ReviewiScience2022

Resilience integrates concepts in aging research.

Daniel Promislow, Rozalyn M Anderson, Marten Scheffer, Bernard Crespi, James DeGregori, Kelley Harris, Barbara Natterson Horowitz, Morgan E Levine, Maria A Riolo, David S Schneider and 3 more

Abstract readReview
In one paragraph

Review in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Age-related behavioral resilience in smartphone touchscreen interaction dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Agency and Mental Health Among Peruvian Older Adults During the COVID-19 Lockdown.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel PromislowDepartment of Lab Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Rozalyn M AndersonDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.
Marten SchefferDepartment of Aquatic Ecology and Water Quality Management, Wageningen University, Wageningen, the Netherlands.
Bernard CrespiDepartment of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
James DeGregoriDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kelley HarrisDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Barbara Natterson HorowitzDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Morgan E LevineDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06524, USA.
Maria A RioloSanta Fe Institute, Santa Fe, NM 87501, USA.
David S SchneiderDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Sabrina L SpencerDepartment of Biochemistry and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA.
Dario Riccardo ValenzanoMax Planck Institute for Biology of Ageing, Cologne, Germany.
Michael E HochbergSanta Fe Institute, Santa Fe, NM 87501, USA.

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Maitreya J Dunham · 1995 to 2026
$27.1M
Dietary Restriction and Aging in Rhesus MonkeysR01AG040178 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ANDERSON, ROZALYN M., COLMAN, RICKI J · 2011 to 2020
$5.8M
Acetyl-CoA flux and mitochondrial adaptation: a pathogenic role in aging and AD?RF1AG057408 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ANDERSON, ROZALYN M., PUGLIELLI, LUIGI · 2017 to 2017
$3.5M
Metabolism of Alzheimer’s Disease: systems and cellular networksR01AG067330 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ANDERSON, ROZALYN M. · 2020 to 2024
$3.4M
Molecular Networks in Aging and Caloric Restriction in Rhesus MonkeysR01AG074503 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson · 2022 to 2026
$3.1M
Investigating the landscape and genetic architecture of germline mutagenesisR35GM133428 · NIGMS · UNIVERSITY OF WASHINGTON · PI Kelley Harris · 2019 to 2026
$2.8M
Preventing Cognitive Decline and Dementia Among Older Chinese Immigrants: The Role of Activity, Engagement, Immigration Experience, and Neighborhood EnvironmentsR01AG067548 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, FENGYAN · 2020 to 2023
$2.2M
Metabolome-Genome Associations for Determining Mechanisms of Aging in DrosophilaR01AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2015 to 2019
$1.8M
Using metabolomics to identify mechanisms of natural variation in agingR56AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD, VILLEN, JUDIT · 2022 to 2022
$319k
Adiponectin signaling in sarcopenia development and treatmentI01BX003846 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI ANDERSON, ROZALYN M. · 2018 to 2023
–
BLRD VA I01 BX003846NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG040178NIA NIH HHS R01 AG049494NIA NIH HHS R01 AG067330NIA NIH HHS R01 AG067548NIA NIH HHS R01 AG074503NIA NIH HHS R56 AG049494NIA NIH HHS RF1 AG057408NIGMS NIH HHS R35 GM133428
6 · The paper itself

Abstract

Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging.

Indexed as

Biological sciencesCell biologyEvolutionary biologyHealth sciencesMolecular biology

Identifiers

PMID35494229
PMCPMC9044173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.