Evidence map›Paper›PMID 35494062›Full record

ArticleFrontiers in oncology2022

Diffuse Large B-Cell Lymphoma Promotes Endothelial-to-Mesenchymal Transition

Xianting Sun, Jianchen Fang, Fen Ye, Shuxian Zhang, Honghui Huang, Jian Hou, Ting Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  6. Unleashing Wnts: Wnt Ligands Fuel Cancer Spread.Journal of cancer biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xianting SunDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Jianchen FangDepartment of Pathology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Fen YeDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shuxian ZhangDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Honghui HuangDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Jian HouDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Ting WangDepartment of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Renji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is one type of highly heterogeneous lymphoid malignancy with 30%~40% of patients experiencing treatment failure. Novel risk stratification and therapeutic approaches for DLBCL are urgently needed. Endothelial-to-mesenchymal transition (EndMT), which contributes to tumor angiogenesis, metastasis, drug resistance, and cancer-associated fibroblast generation, has been detected in the microenvironment of many types of cancers. However, the existence of EndMT in the hematological malignancies microenvironment remains unknown. Here, we identified the existence of EndMT in DLBCL-associated endothelial cells and the clinical relevance of EndMT markers in DLBCL, which was associated with advanced clinical stage and poor prognosis.

Indexed as

angiogenesisdiffuse large B-cell lymphomaendothelial-to-mesenchymal transitionsnailWNT/β-catenin

Identifiers

PMID35494062
PMCPMC9039659
OpenAlexW4223640822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.