ReviewFrontiers in oncology2022
From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia.
Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pulmonary Epithelioid Trophoblastic Tumor Without Demonstrable Uterine Involvement: A Case Report and Literature Review Highlighting Diagnostic Challenges and Multidisciplinary Management.Journal of clinical medicine · 2026Article
- Hemostatic Radiotherapy for Life-Threatening Vaginal Hemorrhage in High-Risk Gestational Trophoblastic Neoplasia Following Partial Hydatidiform Mole: A Rare Case Report.International journal of women's health · 2026Article
- Post-term gestational choriocarcinoma presenting with hemorrhagic brain and bilateral renal metastases: a rare case report.Annals of medicine and surgery (2012) · 2025Article
- A Rare Case of Choriocarcinoma With Myometrial Invasion Mimicking Invasive Mole: Case Report.Clinical case reports · 2025Article
- Diagnosis and management of gestational trophoblastic disease: 2025 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Prognosticating gestational trophoblastic neoplasia: from FIGO 2000 to future models.EClinicalMedicine · 2024Review
- Clinical features and demographic characteristics of gestational trophoblastic neoplasia: Single center experience and the SEER database.Biomolecules & biomedicine · 2024Article
- Intracardiac metastasis of gestational choriocarcinoma: a case report and literature review.BMC pregnancy and childbirth · 2024Review
- Progress of immunotherapies in gestational trophoblastic neoplasms.Journal of cancer research and clinical oncology · 2023Review
- Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt.Cancers · 2023Review
- Article
- Subarachnoid hemorrhage in a postpartum mother: A rare manifestation of an uncommon disease.Gynecologic oncology reports · 2022Article
- Analysis of the Outcome of Treatment of Brain Metastases from Malignant Trophoblastic Tumours and Risk Factors for Prognosis during Pregnancy.Contrast media & molecular imaging · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, we provide the state of the art about brain metastases (BMs) from gestational trophoblastic neoplasia (GTN), a rare condition. Data concerning the epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes of GTN BMs are comprehensively presented with particular attention to the role of radiotherapy, neurosurgery, and the most recent chemotherapy regimens. Good response rates have been achieved thanks to multi-agent chemotherapy, but brain involvement by GTNs entails significant risks for patients' health since sudden and extensive intracranial hemorrhages are possible. Moreover, despite the evolution of treatment protocols, a small proportion of these patients ultimately develops a resistant disease. To tackle this unmet clinical need, immunotherapy has been recently proposed. The role of this novel option for this subset of patients as well as the achieved results so far are also discussed.
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