ArticleFrontiers in behavioral neuroscience2022
Brain Structural Correlates of Dispositional Insight and the Mediation Role of Neuroticism in Young Adults.
Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Network-based mapping and neurotransmitter architecture of gray matter correlates of neuroticism.Frontiers in systems neuroscience · 2025Article
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6 authors at 3 institutions in 1 country.
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Abstract
Studies on the neural correlates of episodic insight have made significant progress in the past decades. However, the neural mechanisms underlying dispositional insight are largely unknown. In the present study, we recruited forty-four young, healthy adults and performed several analyses to reveal the neural mechanisms of dispositional insight. Firstly, a voxel-based morphometry (VBM) technique was used to explore the structural brain mechanisms of dispositional insight. We found that dispositional insight was significantly and negatively correlated with the regional gray matter volume (rGMV) in the left thalamus (TLM.L), right temporoparietal junction (TPJ.R), and left dorsal medial prefrontal cortex (DMPFC.L). Secondly, we performed a seed-based resting-state functional connectivity (RSFC) analysis to complement the findings of VBM analysis further. The brain regions of TLM.L, DMPFC.L, and TPJ.R were selected as seed regions. We found that dispositional insight was associated with altered RSFC between the DMPFC.L and bilateral TPJ, between the TPJ.R and left dorsolateral prefrontal cortex, left ventrolateral prefrontal cortex, DMPFC.L, TPJ.L, right insula, and right cerebellum. Finally, a mediation analysis found that the personality of neuroticism partially mediated the relationship between the brain region of TLM.L and dispositional insight. These findings imply that dispositional insight has a specific functional and structural neural mechanism. The personality of neuroticism may play a pivotal role in the processes of dispositional insight.
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