Evidence map›Paper›PMID 35493938›Full record

ArticleFrontiers in aging neuroscience2022

Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study.

Yu-Qian Wu, Yi-Ning Wang, Li-Juan Zhang, Li-Qi Liu, Yi-Cong Pan, Ting Su, Xu-Lin Liao, Hui-Ye Shu, Min Kang, Ping Ying and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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  5. Review
  6. Article
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  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yu-Qian WuDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yi-Ning WangDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Li-Juan ZhangDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Li-Qi LiuDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yi-Cong PanDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Ting SuDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.
Xu-Lin LiaoDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.
Hui-Ye ShuDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Min KangDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Ping YingDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
San-Hua XuDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yi ShaoDepartment of Ophthalmology and Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To analyze the potential changes in brain neural networks in resting state functional magnetic resonance imaging (rs-fMRI) scans by regional homogeneity (ReHo) in patients with mild cognitive impairment (MCI). Methods: We recruited and selected 24 volunteers, including 12 patients (6 men and 6 women) with MCI and 12 healthy controls matched by age, sex, and lifestyle. All subjects were examined with rs-fMRI to evaluate changes in neural network connectivity, and the data were analyzed by ReHo method. Correlation analysis was used to investigate the relationship between ReHo values and clinical features in different brain regions of MCI patients. The severity of MCI was determined by the Mini-Mental State Examination (MMSE) scale. Results: The signals of the right cerebellum areas 4 and 5, left superior temporal, right superior temporal, left fusiform, and left orbital middle frontal gyri in the patient group were significantly higher than those in the normal group ( Conclusion: Mild cognitive impairment in patients with pre- Alzheimer's disease may be related to the excitation and inhibition of neural networks in these regions. This may have a certain guiding significance for clinical diagnosis.

Indexed as

Alzheimer’s diseasemild cognitive impairmentReHors-fMRIspontaneous brain activity

Identifiers

PMID35493938
PMCPMC9050296

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.