ArticleFrontiers in aging neuroscience2022
Higher Grade Glioma Increases the Risk of Postoperative Delirium: Deficient Brain Compensation Might Be a Potential Mechanism of Postoperative Delirium.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Trial
- Subcortical and Cerebellar Compensation for Motor Control in Medial Frontal Glioblastoma: A Task-Based Connectivity Study.Brain topography · 2026Article
- Association between acute kidney injury and delirium in critically ill patients: a retrospective cohort study using two independent databases.Critical care (London, England) · 2026Article
- Evidence for cognitive compensation mechanism in the postoperative delirium: a prospective multi-modal neuroimaging cohort study.Brain imaging and behavior · 2025Article
- Occurrence Rates of Delirium in Brain Tumor Patients: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- A longitudinal multimodal MRI study of the visual network in postoperative delirium.Brain imaging and behavior · 2024Article
- Article
- Structural changes in eloquent cortex secondary to glioma in sensorimotor area.Human brain mapping · 2024Article
- The characteristics of auditorial event-related potential under propofol sedation associated with preoperative cognitive performance in glioma patients.Frontiers in neuroscience · 2024Article
- Identifying hormones and other perioperative risk factors for postoperative delirium after endoscope-assisted transsphenoidal pituitary adenoma resection: A retrospective, matched cohort study.Brain and behavior · 2023Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The brain compensation mechanism in postoperative delirium (POD) has not been reported. We uncovered the mechanism by exploring the association between POD and glioma grades, and the relationship between preoperative brain structural and functional compensation with POD in patients with frontal glioma. Methods: A total of 335 adult patients with glioma were included. The multivariable analysis examined the association between tumor grade and POD. Then, 20 patients with left frontal lobe glioma who had presurgical structural and functional MRI data and Montreal Cognitive Assessment (MoCA) in this cohort were analyzed. We measured the gray matter volume (GMV) and functional connectivity (FC) in patients with ( Results: The incidence of POD was 37.3%. Multivariable regression revealed that high-grade glioma had approximately six times the odds of POD. Neuroimaging data showed that compared with HC, the patients with left frontal lobe glioma showed significantly increased GMV of the right dorsal lateral prefrontal cortex (DLPFC) in the non-POD group and decreased GMV of right DLPFC in the POD group, and the POD group exhibited significantly decreased FC of right DLPFC, and the non-POD group showed the increasing tendency. Partial correlation analysis showed that GMV in contralesional DLPFC were positively correlated with preoperative neurocognition, and the GMV and FC in contralesional DLPFC were negatively correlated with POD. Conclusions: Our findings suggested that insufficient compensation for injured brain regions involving cognition might be more vulnerable to suffering from POD.
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