Evidence map›Paper›PMID 35493482›Full record

ArticleFrontiers in immunology2022

SARS-CoV-2 Spike Protein Expression

Richard Stebbings, Christopher Jones, Peter Cotton, Gillian Armour, Shaun Maguire, Vicky Skellett, Chi-Man Tang, Joanne Goodman, Tyler Brady, Virginia Takahashi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Richard StebbingsOncology Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Melbourn, United Kingdom.
Christopher JonesIntegrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Peter CottonResearch and Development, BioPharmaceuticals R&D, AstraZeneca, Macclesfield, United Kingdom.
Gillian ArmourRegulatory Toxicology and Safety Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Melbourn, United Kingdom.
Shaun MaguireRegulatory Toxicology and Safety Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Melbourn, United Kingdom.
Vicky SkellettIntegrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Chi-Man TangIntegrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Joanne GoodmanIntegrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Tyler BradyTranslational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States.
Virginia TakahashiMicrobiome Discovery, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States.
Andrew DauntLabcorp Early Development Laboratories Limited, Harrogate, United Kingdom.
Jean-Martin LapointeOncology Safety Pathology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Taylor S CohenMicrobiome Discovery, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States.
AstraZeneca (United Kingdom) · GBAstraZeneca (United States) · USMelbourn Science Park · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe COVID-19 can be associated with a prothrombotic state, increasing risk of morbidity and mortality. The SARS-CoV-2 spike glycoprotein is purported to directly promote platelet activation

Indexed as

COVID-19HematologyViral VaccinesAnimalsAntibodies, ViralChAdOx1 nCoV-19COVID-19 VaccinesHumansMiceMice, Inbred BALB CSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, ViralChAdOx1 nCoV-19COVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Vaccinesadenovirus-vectored vaccineAZD1222 (ChAdOx1 nCoV-19)COVID-19 vaccinationplatelet and white blood cell parametersSARS-CoV-2 spike protein

Identifiers

PMID35493482
PMCPMC9039667
OpenAlexW4223436072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.