Evidence map›Paper›PMID 35493454›Full record

ArticleFrontiers in immunology2022

CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer.

Claire Olingy, Ahmad Alimadadi, Daniel J Araujo, David Barry, Norma A Gutierrez, Max Hardy Werbin, Edurne Arriola, Sandip Pravin Patel, Christian H Ottensmeier, Huy Q Dinh and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claire OlingyCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, United States.
Ahmad AlimadadiCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, United States.
Daniel J AraujoCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, United States.
David BarryCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, United States.
Norma A GutierrezCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, United States.
Max Hardy WerbinCancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
Edurne ArriolaCancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.
Sandip Pravin PatelMoores Cancer Center, University of California, San Diego, La Jolla, CA, United States.
Christian H OttensmeierInstitute of Translational Medicine, Department of Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.
Huy Q DinhMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Catherine C HedrickCenter for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, United States.

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Functions of Nonclassical Monocytes in the VasculatureR01CA202987 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HEDRICK, CATHERINE C · 2016 to 2020
$2.2M
Protective Role of Nonclassical Monocytes in Immunotherapies for Solid CancersU01CA224766 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HEDRICK, CATHERINE C, KAPLAN, ROSANDRA · 2018 to 2021
$1.4M
CyTOF Mass CytometerS10OD018499 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2014 to 2014
$802k
NCI NIH HHS R01 CA202987NCI NIH HHS U01 CA224766NHLBI NIH HHS P01 HL136275NIH HHS S10 OD018499
6 · The paper itself

Abstract

Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths globally. Immune checkpoint blockade (ICB) has transformed cancer medicine, with anti-programmed cell death protein 1 (anti-PD-1) therapy now well-utilized for treating NSCLC. Still, not all patients with NSCLC respond positively to anti-PD-1 therapy, and some patients acquire resistance to treatment. There remains an urgent need to find markers predictive of anti-PD-1 responsiveness. To this end, we performed mass cytometry on peripheral blood mononuclear cells from 26 patients with NSCLC during anti-PD-1 treatment. Patients who responded to anti-PD-1 ICB displayed significantly higher levels of antigen-presenting myeloid cells, including CD9

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsHumansImmunotherapyLeukocytes, MononuclearMonocytesSialic Acid Binding Ig-like Lectin 3CD33 protein, humanSialic Acid Binding Ig-like Lectin 3CD33immunosuppressionimmunotherapymonocytesnon-small cell lung cancer

Identifiers

PMID35493454
PMCPMC9046782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.