ArticleOpen forum infectious diseases2022
Characteristics of Pregnant Women With Syphilis and Factors Associated With Congenital Syphilis at a Chicago Hospital.
Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022.Public health reports (Washington, D.C. : 1974)Pooled it
- A Web-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy: Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Characteristics and effectiveness of maternal health interventions to prevent mother-to-child transmission (PMTCT) of syphilis in a global setting: a scoping review using Intervention Mapping as a framework.BMC pregnancy and childbirth · 2026Article
- Gestational syphilis and prenatal care: a study in light of individual, social, and programmatic vulnerabilities.Revista da Escola de Enfermagem da U S P · 2026Article
- Risk factors and diagnostic indicators for congenital syphilis: a Nationwide retrospective survey.Epidemiology and infection · 2025Article
- Implementation of an Opt-Out and Rapid Point-of-Care Syphilis Testing Program for Pregnant Patients Presenting to the Emergency Department.Sexually transmitted diseases · 2025Article
- Multilevel Drivers of Congenital Syphilis, Oregon, 2013 to 2021.Sexually transmitted diseases · 2025Article
- Factors Related to the Rise of Congenital Syphilis From the Perspectives of Prenatal Providers and Birthing Parents in Chicago, IL, USA.Open forum infectious diseases · 2024Article
- Social Factors Associated With Congenital Syphilis in Missouri.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Review
- Syphilis Complicating Pregnancy and Congenital Syphilis.The New England journal of medicine · 2024Review
- Detection of gestational and congenital syphilis in Paraná state, Brazil, 2007-2021: a time series analysis.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2024Article
- Hospitalizations for congenital syphilis in children under one year old in the state of Pará, Brazilian Amazon: ecological study.BMC pediatrics · 2023Article
- Spike in Congenital Syphilis, Mississippi, USA, 2016-2022.Emerging infectious diseases · 2023Review
- Field Services-Facilitated Treatment and Prevention: Challenges and Opportunities.Sexually transmitted diseases · 2023Article
- Predicting adverse pregnancy outcomes of pregnant mothers with syphilis based on a logistic regression model: a retrospective study.Frontiers in public health · 2023Article
- Intracardiac mass in a 3-month-old boy revealing a congenital syphilis.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
- Adherence to the treatment of gestational syphilis: influence of psychosocial, socioeconomic, and clinical factors.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Congenital syphilis incidence has more than tripled in recent years, in parallel with the resurgence of syphilis among reproductive-aged women. An understanding of risk factors associated with maternal syphilis infection can guide prevention of congenital syphilis through prenatal diagnosis and treatment. We aimed to describe factors associated with maternal syphilis and congenital syphilis at a public medical center in Chicago, Illinois. Methods: Maternal syphilis diagnoses were identified using a database for local health department reporting. Medical records were reviewed for infant congenital syphilis diagnoses, sociodemographic information, medical history, and other behavioral factors. Maternal characteristics associated with congenital syphilis were assessed using logistic regression. Results: Of 106 maternal syphilis diagnoses between 2014 and 2018, 76 (72%) had a known pregnancy outcome; of these, 8 (11%) delivered an infant with congenital syphilis. Women with psychiatric illness and noninjection substance use each had a >5-fold increased odds of having an infant with congenital syphilis. Cases with congenital syphilis were more likely to have late or scant prenatal care and initiated treatment nearly 3 months later in pregnancy. None were human immunodeficiency virus positive or reported incarceration, intravenous substance use, sex work, or having sex with men who have sex with men. Conclusions: Maternal psychiatric illness and substance use may have complicated prenatal care and delayed syphilis treatment, describing a population in need of public health intervention. Women experiencing such barriers to care may benefit from closer follow-up after a prenatal syphilis diagnosis to prevent congenital transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.