Evidence map›Paper›PMID 35493118›Full record

ArticleOpen forum infectious diseases2022

Dolutegravir Resistance in Malawi's National HIV Treatment Program.

Joep J van Oosterhout, Chifundo Chipungu, Lyse Nkhoma, Hope Kanise, Mina C Hosseinipour, Jean Babtiste Sagno, Katherine Simon, Carrie Cox, Risa Hoffman, Kim Steegen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. An audit of the HIV drug resistance testing program in Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2025
    Article
  6. Review
  7. Article
  8. Emergence of Acquired Dolutegravir Resistance in Treatment-experienced People With HIV in Lesotho.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Joep J van OosterhoutPartners in Hope, Lilongwe, Malawi.
Chifundo ChipunguPartners in Hope, Lilongwe, Malawi.
Lyse NkhomaThe Lighthouse Trust, Lilongwe, Malawi.
Hope KanisePartners in Hope, Lilongwe, Malawi.
Mina C HosseinipourUniversity of North Carolina Project Malawi, Lilongwe, Malawi.
Jean Babtiste SagnoDREAM, Communion of St. Egidio, Blantyre, Malawi.
Katherine SimonBaylor College of Medicine Children's Foundation-Malawi, Lilongwe, Malawi.
Carrie CoxBaylor College of Medicine Children's Foundation-Malawi, Lilongwe, Malawi.
Risa HoffmanDivision of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Kim SteegenDepartment of Haematology & Molecular Medicine, National Health Laboratory Service, Johannesburg, South Africa.
Bilaal W MatolaDepartment of Public Health and Family Medicine, Kamuzu University of Health Sciences, Lilongwe, Malawi.
Sam PhiriPartners in Hope, Lilongwe, Malawi.
Andreas JahnDepartment of HIV-AIDS, Ministry of Health, Lilongwe, Malawi.
Rose NyirendaDepartment of HIV-AIDS, Ministry of Health, Lilongwe, Malawi.
Tom HellerThe Lighthouse Trust, Lilongwe, Malawi.
International AIDS Vaccine Initiative · USLighthouse Trust · MWMinistry of Health · MWUniversity of California, Los Angeles · USKamuzu Central Hospital · MWKamuzu University of Health SciencesNational Health Laboratory Service · ZAUniversity of Malawi · MW

Funding

Malawi HIV Implementation Research Scientist Training Program (MHIRST)D43TW010060 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MINA CHRISTINE HOSSEINIPOUR, Victor Mwapasa · 2015 to 2026
$3.8M
FIC NIH HHS D43 TW010060
6 · The paper itself

Abstract

Dolutegravir HIV drug resistance (HIVDR) data from Africa remain sparse. We reviewed HIVDR results of Malawians on dolutegravir-based antiretroviral therapy (November 2020-September 2021). Of 6462 eligible clients, 33 samples were submitted to South Africa, 27 were sequenced successfully, and 8 (30%) had dolutegravir HIVDR. Malawi urgently requires adequate HIVDR testing capacity.

Indexed as

Africaantiretroviral therapydolutegravirHIVMalawiresistance

Identifiers

PMID35493118
PMCPMC9045949
OpenAlexW4225307087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.