Evidence map›Paper›PMID 35493022›Full record

ArticleRSC advances2020

Synthesis of α-indolylacrylates as potential anticancer agents using a Brønsted acid ionic liquid catalyst and the butyl acetate solvent.

Ahmed El-Harairy, Mennatallah Shaheen, Jun Li, Yuzhou Wu, Minghao Li, Yanlong Gu

Abstract read
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In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmed El-HarairyEnvironmental, Energy and Green Chemistry Laboratory, Faculty of Agriculture, Damietta University 34511 Damietta Egypt ahmed.elharairy@hotmail.com.ORCID https://orcid.org/0000-0001-7030-696X
Mennatallah ShaheenDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University 34511 New Damietta Damietta Egypt.ORCID https://orcid.org/0000-0003-1376-8644
Jun LiSchool of Chemistry and Chemical Engineering, Huazhong University of Science and Technology 430074 Wuhan China.
Yuzhou WuSchool of Chemistry and Chemical Engineering, Huazhong University of Science and Technology 430074 Wuhan China.ORCID https://orcid.org/0000-0003-3229-4982
Minghao LiSchool of Chemistry and Chemical Engineering, Huazhong University of Science and Technology 430074 Wuhan China.ORCID https://orcid.org/0000-0003-0221-2405
Yanlong GuSchool of Chemistry and Chemical Engineering, Huazhong University of Science and Technology 430074 Wuhan China.ORCID https://orcid.org/0000-0001-5130-3026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, new α-indolylacrylate derivatives were synthesized by the reaction of 2-substituted indoles with various pyruvates using a Brønsted acid ionic liquid catalyst in butyl acetate solvent. This is the first report on the application of pyruvate compounds for the synthesis of indolylacrylates. The acrylate derivatives could be obtained in good to excellent yields. A preliminary biological evaluation revealed their promising anticancer activity (IC

Identifiers

PMID35493022
PMCPMC9051412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.