Evidence map›Paper›PMID 35492978›Full record

ArticleRSC advances2020

Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate

Arunan Palanimuthu, Chinpiao Chen, Gene-Hsian Lee

Abstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arunan PalanimuthuDepartment of Chemistry, National Dong Hwa University Soufeng Hualien 974 Taiwan.ORCID https://orcid.org/0000-0002-9907-8777
Chinpiao ChenDepartment of Nursing, Tzu Chi University of Science and Technology Hualien 970 Taiwan chinpiao@ems.tcust.edu.tw +886 3 856 1097 +886 3 857 2158 ext. 2624.ORCID https://orcid.org/0000-0002-9904-1085
Gene-Hsian LeeInstrumentation Center, College of Science, National Taiwan University Taipei 106 Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A three-component cascade reaction involving 2-alkenyl aniline, aldehydes, and ethyl cyanoacetate in the presence of DBU to synthesize highly substituted 1,2,3,4-tetrahydroquinolines is reported. The reaction proceeded through the Knoevenagel condensation of ethyl cyanoacetate with aldehydes followed by the aza-Michael-Michael addition with 2-alkenyl anilines to prepare the tetrahydroquinoline scaffolds.

Identifiers

PMID35492978
PMCPMC9051536

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.