ArticleRSC advances2019
Pulse electromagnetic fields enhance the repair of rabbit articular cartilage defects with magnetic nano-hydrogel.
Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Overview of Magnetic Hydrogel Fabrication, Its Basic Characteristics, and Potential Uses in Biomedical Engineering.Bioengineering (Basel, Switzerland) · 2025Review
- Magnetic Polymeric Conduits in Biomedical Applications.Micromachines · 2025Review
- Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review.Bioactive materials · 2025Review
- Nanostructures in Orthopedics: Advancing Diagnostics, Targeted Therapies, and Tissue Regeneration.Materials (Basel, Switzerland) · 2024Review
- Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation.Polymers · 2024Review
- Energizing Healing with Electromagnetic Field Therapy in Musculoskeletal Disorders.Journal of orthopaedics and sports medicine · 2024Article
- Stimulation strategies for electrical and magnetic modulation of cells and tissues.Cell regeneration (London, England) · 2023Review
- The advances in nanomedicine for bone and cartilage repair.Journal of nanobiotechnology · 2022Review
- Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering.Gels (Basel, Switzerland) · 2022Review
- Advanced Hydrogels With Nanoparticle Inclusion for Cartilage Tissue Engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Magnetic Hydrogel for Cartilage Tissue Regeneration as well as a Review on Advantages and Disadvantages of Different Cartilage Repair Strategies.BioMed research international · 2022Review
- 3D Bioprinting of Hydrogels for Cartilage Tissue Engineering.Gels (Basel, Switzerland) · 2021Review
- Magnetic Nanoparticles and Magnetic Field Exposure Enhances Chondrogenesis of Human Adipose Derived Mesenchymal Stem Cells But Not of Wharton Jelly Mesenchymal Stem Cells.Frontiers in bioengineering and biotechnology · 2021Article
- Review
- Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective.Bioengineering (Basel, Switzerland) · 2020Review
- Preparation, Characterization, and Biological Testing of Novel Magnetic Nanocomposite Hydrogels.ACS omega · 2020Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogel is an important scaffold material in regenerative medicine and cartilage tissue engineering. Hydrogel material combined with pulse electromagnetic fields (PEMFs), PEMFs has the potential to manage the repair of defective articular cartilage. Here, we developed a new type of magnetic hydrogel. The data shows that the magnetic hydrogel had good mechanical properties, and its surface had micropores and unevenness, which was conducive to cell adhesion growth. Infrared spectroscopy analysis showed that the magnetic particles were evenly distributed in the hydrogel, and the addition of constant static magnetic field yielded magnetic water. The hydrogel exhibited good superparamagnetism. The co-culture of the magnetic hydrogel and bone marrow mesenchymal stem cells (BMSCs) showed good biocompatibility. The PEMFs promoted the differentiation of the BMSCs into cartilage, and the index of cartilage differentiation increased obviously. The results of the animal experiments showed that the magnetic hydrogel and BMSCs combined with pulsed electromagnetic field had a strong repair effect. They also showed that the magnetic nano-hydrogel combined with the PEMFs induced chondrogenic differentiation of the BMSCs. The positive experimental results suggested that the combination of magnetic hydrogel and the PEMFs can be used as an effective method for repairing articular cartilage defects in rabbit model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.