Evidence map›Paper›PMID 35492524›Full record

ArticleRSC advances2019

Rapid, quantitative and ultra-sensitive detection of cancer biomarker by a SERRS-based lateral flow immunoassay using bovine serum albumin coated Au nanorods.

Luchun Lu, Jiangliu Yu, Xiaoxian Liu, Xingsheng Yang, Zihui Zhou, Qing Jin, Rui Xiao, Chongwen Wang

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 49 citations in OpenAlex.

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  16. Metal Nanoparticles/MoSACS applied materials & interfaces · 2021
    Article
  17. Review
  18. Rapid, Quantitative, High-Sensitive Detection ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Luchun LuCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.
Jiangliu YuCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.
Xiaoxian LiuCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.
Xingsheng YangCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.
Zihui ZhouAnhui Provincial Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University Hefei 230036 PR China.
Qing JinCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.
Rui XiaoCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.
Chongwen WangCollege of Life Sciences, Anhui Agricultural University Hefei 230036 PR China jinqing169@126.com ruixiao203@sina.com wangchongwen1987@126.com.ORCID https://orcid.org/0000-0002-9627-107X
Anhui Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis of cancer biomarkers is the key to guiding treatments and improving the survival rate of patients. Herein, we report a novel surface-enhanced resonance Raman scattering (SERRS)-based lateral flow immunoassay (LFIA) for quantitative and ultra-sensitive analysis of alpha-fetoprotein (AFP). Gold nanorods (AuNRs) were fabricated to be in resonance with 785 nm laser excitation, that is, the excitation level that can maximize SERRS activity. The AuNRs were modified with 5,5'-dithiobis(2-nitrobenzoic acid), bovine serum albumin (BSA), and AFP detection antibody successively as the SERRS nanotags for the LFIA system. Modification of the BSA layer guaranteed good stability and biocompatibility of the SERRS nanotags in complex samples. The SERRS-LFIA strip for AFP detection showed a low detection limit of 9.2 pg mL

Identifiers

PMID35492524
PMCPMC9047559
OpenAlexW2998225340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.