Evidence map›Paper›PMID 35492392›Full record

ArticleCurrent research in immunology2021

Shared inflammatory and skin-specific gene signatures reveal common drivers of discoid lupus erythematosus in canines, humans and mice.

Colton J Garelli, Neil B Wong, Cesar Piedra-Mora, Linda M Wrijil, Gina Scarglia, Clement N David, Ramón M Almela, Nicholas A Robinson, Jillian M Richmond

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Colton J GarelliDermatology Department, University of Massachusetts Medical School, Worcester, MA, USA.
Neil B WongDermatology Department, University of Massachusetts Medical School, Worcester, MA, USA.
Cesar Piedra-MoraDepartment of Biomedical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton MA, USA.
Linda M WrijilDepartment of Biomedical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton MA, USA.
Gina ScargliaDepartment of Biomedical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton MA, USA.
Clement N DavidNanoString Technologies, Seattle, WA, USA.
Ramón M AlmelaDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA.
Nicholas A RobinsonDepartment of Biomedical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton MA, USA.
Jillian M RichmondDermatology Department, University of Massachusetts Medical School, Worcester, MA, USA.
Tufts University · USUniversity of Massachusetts Chan Medical School · USNanostring Technologies (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune skin diseases are complex and are thought to arise from a combination of genetics and environmental exposures, which trigger an ongoing immune response against self-antigens. Companion animals including cats and dogs are known to develop inflammatory skin conditions similar to humans and share the same environment, providing opportunities to study spontaneous disease that encompasses genetic and environmental factors with a One Health approach. A strength of comparative immunology approaches is that immune profiles may be assessed across different species to better identify shared or conserved pathways that might drive inflammation. Here, we performed a comparative study of skin from canine discoid lupus erythematosus (DLE) using NanoString nCounter technology. We compared these gene expression patterns to those of human DLE and a mouse model of cutaneous lupus. We found strong interferon signatures, with

Indexed as

Canine (dog)ChemokineComparative immunologyCutaneous lupus erythematosusCytokineDiscoid lupusImmunopathogenesisSkin

Identifiers

PMID35492392
PMCPMC9040131
OpenAlexW3151427470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.