Diabetic Retinopathy Grading by Deep Graph Correlation Network on Retinal Images Without Manual Annotations.

Background: Diabetic retinopathy, as a severe public health problem associated with vision loss, should be diagnosed early using an accurate screening tool. While many previous deep learning models have been proposed for this disease, they need sufficient professional annotation data to train the model, requiring more expensive and time-consuming screening skills. Method: This study aims to economize manual power and proposes a deep graph correlation network (DGCN) to develop automated diabetic retinopathy grading without any professional annotations. DGCN involves the novel deep learning algorithm of a graph convolutional network to exploit inherent correlations from independent retinal image features learned by a convolutional neural network. Three designed loss functions of graph-center, pseudo-contrastive, and transformation-invariant constrain the optimisation and application of the DGCN model in an automated diabetic retinopathy grading task. Results: To evaluate the DGCN model, this study employed EyePACS-1 and Messidor-2 sets to perform grading results. It achieved an accuracy of 89.9% (91.8%), sensitivity of 88.2% (90.2%), and specificity of 91.3% (93.0%) on EyePACS-1 (Messidor-2) data set with a confidence index of 95% and commendable effectiveness on receiver operating characteristic (ROC) curve and t-SNE plots. Conclusion: The grading capability of this study is close to that of retina specialists, but superior to that of trained graders, which demonstrates that the proposed DGCN provides an innovative route for automated diabetic retinopathy grading and other computer-aided diagnostic systems.