ArticleRSC advances2020
The effect of size and surface ligands of iron oxide nanoparticles on blood compatibility.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 60 citations in OpenAlex.
- Magnetic Field-Driven Strategies for Biofilm Disruption: From Iron Oxide Nanoparticles to Adaptive Swarms of Magnetic Microrobots.ACS nano · 2026Review
- Ultrasonic irradiation in the synthesis of nanohydroxyapatite: a chemically friendly technique for improving hemocompatibility and antibiofilm applications.Beilstein journal of nanotechnology · 2026Article
- Regulation of nanomaterials in peripheral nerve regeneration from a microenvironmental perspective: biological effects and mechanisms.Materials today. Bio · 2025Review
- Enhanced detection of glioblastoma vasculature with superparamagnetic iron oxide nanoparticles and MRI.Scientific reports · 2025Article
- Enhanced hemocompatibility, antimicrobial and anti-inflammatory properties of biomolecules stabilized AgNPs with cytotoxic effects on cancer cells.Scientific reports · 2025Article
- Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures.Journal of functional biomaterials · 2024Review
- Stealth and Biocompatible Gold Nanoparticles through Surface Coating with a Zwitterionic Derivative of Glutathione.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of theMaterials (Basel, Switzerland) · 2024Article
- Designing Smart Iron Oxide Nanoparticles for MR Imaging of Tumors.Chemical & biomedical imaging · 2023Review
- Recent advances in the protective role of metallic nanoparticles in red blood cells.3 Biotech · 2022Review
- Recent Advances in the Surface Functionalization of Nanomaterials for Antimicrobial Applications.Materials (Basel, Switzerland) · 2021Review
- Impact of Polyethylene Glycol Functionalization of Graphene Oxide on Anticoagulation and Haemolytic Properties of Human Blood.Materials (Basel, Switzerland) · 2021Article
- Imaging Constructs: The Rise of Iron Oxide Nanoparticles.Molecules (Basel, Switzerland) · 2021Review
- Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization.Frontiers in molecular biosciences · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used and have attracted increased attention for their unique physicochemical properties, especially in biomedical sciences as contrast agents following intravenous administration. However, only few studies have systematically reported the blood compatibility of iron oxide nanoparticles with different physicochemical properties such as different sizes and surface ligands. Therefore, we selected three widely used organic ligands (polyacrylic acid, hyaluronic acid, and chitosan) with modified SPIONs at the same size of 5-6 nm, and polyacrylic acid-modified SPIONs with different sizes (5, 10, and 30 nm) at different concentrations to evaluate their haemocompatibility. Our results revealed that SPIONs modified with polyacrylic acid demonstrated size-dependent destruction of red blood cells and complement activation. Interestingly, 5 nm SPIONs prolonged blood clotting time as compared with 10 nm and 30 nm SPIONs
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.