ArticleRSC advances2020
API ionic liquids: probing the effect of counterion structure on physical form and lipid solubility.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- New Ionic Liquid Forms of Antituberculosis Drug Combinations for Optimized Stability and Dissolution.AAPS PharmSciTech · 2025Article
- Rationalizing Counterion Selection for the Development of Lipophilic Salts: A Case Study with Venetoclax.Molecular pharmaceutics · 2024Article
- Synthesis, characterization and irritant effects of nonivamide irritant riot control agent based on ionic liquids.Frontiers in chemistry · 2024Article
- Effects of Zwitterions on Structural Anomalies in Ionic Liquid Glasses Studied by EPR.Nanomaterials (Basel, Switzerland) · 2023Article
- Role and Recent Advancements of Ionic Liquids in Drug Delivery Systems.Pharmaceutics · 2023Review
- Active Pharmaceutical Ingredient-Ionic Liquids (API-ILs): Nanostructure of the Glassy State Studied by Electron Paramagnetic Resonance Spectroscopy.Molecules (Basel, Switzerland) · 2022Article
- Synthesis and Characterization of Lipophilic Salts of Metformin to Improve Its Repurposing for Cancer Therapy.ACS omega · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid based formulations (LBFs) are extensively utilised as an enabling technology in drug delivery. The use of ionic liquids (ILs) or lipophilic salts (LS) in drug delivery has also garnered considerable interest due to unique solubility properties. Conversion of active pharmaceutical ingredients (API) to ILs by pairing with an appropriately lipophilic counterion has been shown to decrease melting point of the salt complex and improve solubility in LBFs. However, the relationship between the structure of the counterion, the physicochemical properties of the resulting salts and solubility in LBFs has not been systematically explored. This study investigates the relationship between alkyl sulfate counterion structure and melting temperature (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.