Evidence map›Paper›PMID 35492070›Full record

ArticleRSC advances2021

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and

Dalia Elebeedy, Walid F Elkhatib, Ahmed Kandeil, Aml Ghanem, Omnia Kutkat, Radwan Alnajjar, Marwa A Saleh, Ahmed I Abd El Maksoud, Ingy Badawy, Ahmed A Al-Karmalawy

Abstract read
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Antiviral Activity and Underlying Mechanism ofMolecules (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Article
  12. Network Pharmacology andCurrent pharmaceutical design · 2025
    Article
  13. Article
  14. Chemoinformatics analysis ofFrontiers in chemistry · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dalia ElebeedyCollege of Biotechnology, Misr University for Science and Technology (MUST) 6th of October City Egypt.
Walid F ElkhatibMicrobiology and Immunology Department, Faculty of Pharmacy, Ain Shams University, African Union Organization St. Abbassia Cairo 11566 Egypt.
Ahmed KandeilCenter of Scientific Excellence for Influenza Viruses, National Research Centre Giza 12622 Egypt.
Aml GhanemDepartment of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City Sadat City Egypt.
Omnia KutkatCenter of Scientific Excellence for Influenza Viruses, National Research Centre Giza 12622 Egypt.
Radwan AlnajjarDepartment of Chemistry, Faculty of Science, University of Benghazi Benghazi Libya.
Marwa A SalehDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University Nasr City Cairo Egypt.
Ahmed I Abd El MaksoudIndustrial Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City Sadat City Egypt.
Ingy BadawyCollege of Biotechnology, Misr University for Science and Technology (MUST) 6th of October City Egypt.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt akarmalawy@horus.edu.eg.ORCID https://orcid.org/0000-0002-8173-6073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Six compounds namely, tanshinone IIA (1), carnosic acid (2), rosmarinic acid (3), salvianolic acid B (4), baicalein (5), and glycyrrhetinic acid (6) were screened for their anti-SARS-CoV-2 activities against both the spike (S) and main protease (Mpro) receptors using molecular docking studies. Molecular docking recommended the superior affinities of both salvianolic acid B (4) and glycyrrhetinic acid (6) as the common results from the previously published computational articles. On the other hand, their actual anti-SARS-CoV-2 activities were tested

Identifiers

PMID35492070
PMCPMC9040650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.