Evidence map›Paper›PMID 35491994›Full record

Observational studyExperimental biology and medicine (Maywood, N.J.)2022

Elevated SARS-CoV-2 in peripheral blood and increased COVID-19 severity in American Indians/Alaska Natives.

Douglas J Perkins, Alexandra V Yingling, Qiuying Cheng, Amber Castillo, Janae Martinez, Steven B Bradfute, Shuguang Leng, Jeremy Edwards, Yan Guo, Gregory Mertz and 9 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. A systematic review of obstructive sleep apnea in Indigenous peoples worldwide.Sleep advances : a journal of the Sleep Research Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Douglas J PerkinsCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0001-9390-6255
Alexandra V YinglingCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Qiuying ChengCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Amber CastilloCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-9037-9215
Janae MartinezCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Steven B BradfuteCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-1985-751X
Shuguang LengDivision of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Jeremy EdwardsDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Yan GuoDivision of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Gregory MertzCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Michelle HarkinsDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-9679-2553
Mark UnruhDivision of Nephrology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Anthony WorshamDivision of Hospital Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Christophe G LambertCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0003-1994-2893
J Pedro TeixeiraDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-2466-9644
Phillip SeidenbergDepartment of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Jens LangsjoenDivision of Hospital Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Kristan SchneiderDepartment of Applied Computer- and Bio-Sciences, University of Applied Sciences, Mittweida 09648, Germany.
Ivy HurwitzCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0003-1566-1111
University of New Mexico · USUniversity of New Mexico Hospital · USHochschule Mittweida · DE

Funding

TRAINING AND RESEARCH ON SEVERE MALARIAL ANEMIAD43TW005884 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Collins Ouma, Douglas Jay Perkins · 2002 to 2026
$5.2M
Temporal Transcriptomics in Hospitalized COVID-19 Patients from Disparately Impacted Ancestral Groups for Therapeutic DiscoveryR01AI160662 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PERKINS, DOUGLAS JAY · 2021 to 2023
$2.3M
FIC NIH HHS D43 TW005884NIAID NIH HHS R01 AI160662
6 · The paper itself

Abstract

Epidemiological data across the United States show health disparities in COVID-19 infection, hospitalization, and mortality by race/ethnicity. While the association between elevated SARS-CoV-2 viral loads (VLs) (i.e. upper respiratory tract (URT) and peripheral blood (PB)) and increased COVID-19 severity has been reported, data remain largely unavailable for some disproportionately impacted racial/ethnic groups, particularly for American Indian or Alaska Native (AI/AN) populations. As such, we determined the relationship between SARS-CoV-2 VL dynamics and disease severity in a diverse cohort of hospitalized patients. Results presented here are for study participants (

Indexed as

American Indian or Alaska NativeCOVID-19SARS-CoV-2Viral LoadAdultAgedAged, 80 and overEthnicityHumansMiddle AgedRacial GroupsUnited StatesYoung AdultCOVID-19hospitalizationintensive carerace/ethnicitySARS-CoV-2viral load

Identifiers

PMID35491994
PMCPMC9379605
OpenAlexW4225252383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.