Evidence map›Paper›PMID 35491954›Full record

ArticleTransboundary and emerging diseases2022

Serological evidence of a pararubulavirus and a betacoronavirus in the geographically isolated Christmas Island flying-fox (Pteropus natalis).

Laura A Pulscher, Alison J Peel, Karrie Rose, Justin A Welbergen, Michelle L Baker, Victoria Boyd, Samantha Low-Choy, Dan Edson, Christopher Todd, Annabel Dorrestein and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 2 countries.

Laura A PulscherFaculty of Science, Sydney School of Veterinary Science, University of Sydney, Sydney, New South Wales, Australia.
Alison J PeelCentre for Planetary Health and Food Security, Griffith University, Nathan, Queensland, Australia.ORCID https://orcid.org/0000-0003-3538-3550
Karrie RoseAustralian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, New South Wales, Australia.
Justin A WelbergenHawkesbury Institute for the Environment, Western Sydney University, Richmond, New South Wales, Australia.
Michelle L BakerAustralian Centre for Disease Preparedness, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organization, Geelong, Victoria, Australia.
Victoria BoydAustralian Centre for Disease Preparedness, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organization, Geelong, Victoria, Australia.
Samantha Low-ChoyCentre for Planetary Health and Food Security, Griffith University, Nathan, Queensland, Australia.
Dan EdsonDepartment of Agriculture, Water and the Environment, Canberra, Australian Capital Territory, Australia.
Christopher ToddHawkesbury Institute for the Environment, Western Sydney University, Richmond, New South Wales, Australia.
Annabel DorresteinHawkesbury Institute for the Environment, Western Sydney University, Richmond, New South Wales, Australia.
Jane HallAustralian Registry of Wildlife Health, Taronga Conservation Society Australia, Mosman, New South Wales, Australia.
Shawn ToddAustralian Centre for Disease Preparedness, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organization, Geelong, Victoria, Australia.
Christopher C BroderDepartment of Microbiology, Uniformed Services University, Bethesda, Maryland, USA.
Lianying YanDepartment of Microbiology, Uniformed Services University, Bethesda, Maryland, USA.
Kai XuDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Grantley R PeckAustralian Centre for Disease Preparedness, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organization, Geelong, Victoria, Australia.
David N PhalenFaculty of Science, Sydney School of Veterinary Science, University of Sydney, Sydney, New South Wales, Australia.
Australian Centre for Disease Preparedness · AUWestern Sydney University · AUGriffith University · AUTaronga Conservation Society Australia · AUThe University of Sydney · AUDepartment of Agriculture, Water and the Environment · AUHenry M. Jackson Foundation · USThe Ohio State University · USUniformed Services University of the Health Sciences · US

Funding

Project 3 - USUHSU19AI142764 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BRODER, CHRISTOPHER C · 2019 to 2023
$24.6M
ARC DECRA fellowship DE190100710Christmas Island National ParkDepartment of Agriculture, Water and the Environment, Australian GovernmentMarie Bashir Institute, University of SydneyNIAID NIH HHS U19 AI142764NIH HHS AI142764Sydney School of Veterinary Science at the University of SydneyTaronga Conservation Society Australia's Taronga Foundation
6 · The paper itself

Abstract

Due to their geographical isolation and small populations, insular bats may not be able to maintain acute immunizing viruses that rely on a large population for viral maintenance. Instead, endemic transmission may rely on viruses establishing persistent infections within hosts or inducing only short-lived neutralizing immunity. Therefore, studies on insular populations are valuable for developing broader understanding of viral maintenance in bats. The Christmas Island flying-fox (CIFF; Pteropus natalis) is endemic on Christmas Island, a remote Australian territory, and is an ideal model species to understand viral maintenance in small, geographically isolated bat populations. Serum or plasma (n = 190), oral swabs (n = 199), faeces (n = 31), urine (n = 32) and urine swabs (n = 25) were collected from 228 CIFFs. Samples were tested using multiplex serological and molecular assays, and attempts at virus isolation to determine the presence of paramyxoviruses, betacoronaviruses and Australian bat lyssavirus. Analysis of serological data provides evidence that the species is maintaining a pararubulavirus and a betacoronavirus. There was little serological evidence supporting the presence of active circulation of the other viruses assessed in the present study. No viral nucleic acid was detected and no viruses were isolated. Age-seropositivity results support the hypothesis that geographically isolated bat populations can maintain some paramyxoviruses and coronaviruses. Further studies are required to elucidate infection dynamics and characterize viruses in the CIFF. Lastly, apparent absence of some pathogens could have implications for the conservation of the CIFF if a novel disease were introduced into the population through human carriage or an invasive species. Adopting increased biosecurity protocols for ships porting on Christmas Island and for researchers and bat carers working with flying-foxes are recommended to decrease the risk of pathogen introduction and contribute to the health and conservation of the species.

Indexed as

ChiropteraLyssavirusNucleic AcidsAnimalsAustraliaBetacoronavirusHumansNucleic Acidsbatbetacoronavirusinsular populationspararubulavirusPteropodidaeviral maintenance

Identifiers

PMID35491954
PMCPMC9529767
OpenAlexW4225276366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.