Evidence map›Paper›PMID 35491910›Full record

ArticleEuropean journal of immunology2022

Alterations of blood monocyte subset distribution and surface phenotype are linked to infection severity in COVID-19 inpatients.

David Haschka, Verena Petzer, Francesco Robert Burkert, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Piotr Tymoszuk, Guenter Weiss

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

David HaschkaDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-8028-1030
Verena PetzerDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Francesco Robert BurkertDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Gernot FritscheDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Sophie WildnerDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Rosa Bellmann-WeilerDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Piotr TymoszukDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Guenter WeissDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe coronavirus disease 19 (COVID-19) manifests with systemic immediate proinflammatory innate immune activation and altered iron turnover. Iron homeostasis, differentiation, and function of myeloid leukocytes are interconnected. Therefore, we characterized the cellularity, surface marker expression, and iron transporter phenotype of neutrophils and monocyte subsets in COVID-19 patients within 72 h from hospital admission, and analyzed how these parameters relate to infection severity. Between March and November 2020, blood leukocyte samples from hospitalized COVID-19 patients (n = 48) and healthy individuals (n = 7) were analyzed by flow cytometry enabling comparative analysis of 40 features. Inflammation-driven neutrophil expansion, depletion of CD16

Indexed as

COVID-19MonocytesHumansInflammationInpatientsIronPhenotypeIronCOVID-19immunophenotypingmonocyte subsetsneutrophilsSARS-CoV-2

Identifiers

PMID35491910
PMCPMC9348104
OpenAlexW4225263043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.