Evidence map›Paper›PMID 35491906›Full record

ArticleRNA biology2022

Differential translation elongation directs protein synthesis in response to acute glucose deprivation in yeast.

Anna R Guzikowski, Alex T Harvey, Jingxiao Zhang, Shihui Zhu, Kyle Begovich, Molly H Cohn, James E Wilhelm, Brian M Zid

Open access · goldAbstract read
In one paragraph

Article in RNA biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genes near tRNAs are enriched in translational machinery.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Ribosome biogenesis and function in development and disease.Development (Cambridge, England) · 2023
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anna R GuzikowskiDivision of Biological Sciences, University of California, San Diego, CA, USA.ORCID 0000-0001-5012-9783
Alex T HarveyDepartment of Chemistry & Biochemistry, University of California, San Diego, CA, USA.
Jingxiao ZhangDepartment of Chemistry & Biochemistry, University of California, San Diego, CA, USA.
Shihui ZhuDepartment of Chemistry & Biochemistry, University of California, San Diego, CA, USA.
Kyle BegovichDivision of Biological Sciences, University of California, San Diego, CA, USA.
Molly H CohnDepartment of Chemistry & Biochemistry, University of California, San Diego, CA, USA.
James E WilhelmDivision of Biological Sciences, University of California, San Diego, CA, USA.
Brian M ZidDepartment of Chemistry & Biochemistry, University of California, San Diego, CA, USA.ORCID 0000-0003-1876-2479
University of California San Diego · US

Funding

Undergraduate Summer Research Supplement to R35R35GM128798 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZID, BRIAN MATTHEW · 2018 to 2023
$2.3M
NIGMS NIH HHS R35 GM128798
6 · The paper itself

Abstract

Protein synthesis is energetically expensive and its rate is influenced by factors such as cell type and environment. Suppression of translation is a canonical response to stressful changes in the cellular environment. In particular, inhibition of the initiation step of translation has been highlighted as the key control step in stress-induced translational suppression as mechanisms that quickly suppress initiation are well-conserved. However, cells have evolved complex regulatory means to control translation apart from initiation. Here, we examine the role of the elongation step of translation in yeast subjected to acute glucose deprivation. The use of ribosome profiling and

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsGlucosePeptide Chain Elongation, TranslationalRibosomesGlucoseSaccharomyces cerevisiae Proteinsglucose starvationribosome profilingribosome runofftranslation elongationTranslation regulation

Identifiers

PMID35491906
PMCPMC9067459
OpenAlexW4225259122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.