Evidence map›Paper›PMID 35491817›Full record

ReviewmBio2022

Polymicrobial Interactions of Oral Microbiota: a Historical Review and Current Perspective.

Mengshi Zhang, Marvin Whiteley, Gina R Lewin

Open access · goldAbstract readReview
In one paragraph

Review in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The role ofJournal of oral microbiology · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mengshi ZhangSchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.
Marvin WhiteleySchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.
Gina R LewinSchool of Biological Sciences and Center for Microbial Dynamics and Infection, Georgia Institute of Technologygrid.213917.f, Atlanta, Georgia, USA.ORCID 0000-0002-1189-6696
Georgia Institute of Technology · US

Funding

Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
Metabolite sensing in a polymicrobial infectionR01DE020100 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2011 to 2022
$3.3M
Probing the impact of polymicrobial interactions on the virulence of an oral pathogenF32DE027281 · NIDCR · GEORGIA INSTITUTE OF TECHNOLOGY · PI LEWIN, GINA · 2017 to 2021
$215k
Probing the role of heterogeneity in streptococcal interactionsK99DE031018 · NIDCR · GEORGIA INSTITUTE OF TECHNOLOGY · PI LEWIN, GINA · 2021 to 2022
$120k
NIDCR NIH HHS F32 DE027281NIDCR NIH HHS K99 DE031018NIDCR NIH HHS R01 DE020100NIDCR NIH HHS R01 DE023193
6 · The paper itself

Abstract

The oral microbiota is enormously diverse, with over 700 microbial species identified across individuals that play a vital role in the health of our mouth and our overall well-being. In addition, as oral diseases such as caries (cavities) and periodontitis (gum disease) are mediated through interspecies microbial interactions, this community serves as an important model system to study the complexity and dynamics of polymicrobial interactions. Here, we review historical and recent progress in our understanding of the oral microbiome, highlighting how oral microbiome research has significantly contributed to our understanding of microbial communities, with broad implications in polymicrobial diseases and across microbial community ecology. Further, we explore innovations and challenges associated with analyzing polymicrobial systems and suggest future directions of study. Finally, we provide a conceptual framework to systematically study microbial interactions within complex communities, not limited to the oral microbiota.

Indexed as

MicrobiotaPeriodontitisHumansMicrobial InteractionsModels, BiologicalMouthmicrobe-microbe interactionsmicrobial ecologymicrobiomeoral microbiology

Identifiers

PMID35491817
PMCPMC9239150
OpenAlexW4225275147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.