Evidence map›Paper›PMID 35491792›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Mild Traumatic Brain Injury Is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia.

Christian LoBue, Brendan J Kelley, John Hart, Jessica Helphrey, Jeff Schaffert, C Munro Cullum, Matthew E Peters, Peter M Douglas, Alzheimer’s Disease Neuroimaging Initiative

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian LoBueDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brendan J KelleyDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John HartDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jessica HelphreyDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jeff SchaffertDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
C Munro CullumDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matthew E PetersDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter M DouglasDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Few studies have examined an association between mild traumatic brain injury (mTBI) and Alzheimer's disease (AD). For this reason, we compared an AD dementia group with an mTBI history (n = 10) to a matched AD control group (n = 20) on measures of cognitive function, cerebral glucose metabolism, and markers of amyloid and tau deposition. Only a trend and medium-to-large effect size for higher phosphorylated and total tau was identified for the mTBI group. A history of mTBI may be associated with greater tau in AD, indicating a potential pathway for increasing risk for AD, though further evaluation with larger samples is needed.

Indexed as

Alzheimer DiseaseBrain ConcussionCognitive DysfunctionAmyloidAmyloid beta-PeptidesBiomarkersHumansPeptide Fragmentstau ProteinsAmyloidAmyloid beta-PeptidesBiomarkersPeptide Fragmentstau ProteinsBiomarkersconcussiondementianeurodegenerationrisk factortau formationtraumatic brain injury

Identifiers

PMID35491792
PMCPMC9241585

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.