ArticleInnate immunity2022
The monocyte activation test detects potentiated cytokine release resulting from the synergistic effect of endotoxin and non-endotoxin pyrogens.
Article in Innate immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Quality Control for Medical Devices: A Review of Detection Technologies, Regulatory Standards and Matrix Interference Solutions.Sensors (Basel, Switzerland) · 2026Review
- High-sensitivity electrochemical aptasensor based on AuNPs/NHMikrochimica acta · 2026Article
- TLR7/8 signaling balances cytokine responses in neonatal monocytes.Scientific reports · 2026Article
- Defined culture conditions improve functional properties of mature iPSC-derived macrophages for therapeutic screening.Stem cell research & therapy · 2026Article
- Applicability of Whole Blood Monocyte Activation Test for Endotoxin Activity Assessment in Hydroxyapatite-Based Ceramics.Bioengineering (Basel, Switzerland) · 2026Article
- Review
- Fit for purpose testing and independent GMP validation of the monocyte activation test.Current research in toxicology · 2025Article
- Analytical Techniques for the Characterization and Quantification of Monoclonal Antibodies.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Sensitive detection of lipopolysaccharides by monitoring of interleukin-10 secretion from human PBMCs.microPublication biology · 2023Article
- Peripheral blood mononuclear cell phenotype and function are maintained after overnight shipping of whole blood.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrogens are classified in two groups, endotoxin pyrogens and non-endotoxin pyrogens (NEPs). The presence of either in parenteral pharmaceuticals or medical devices can cause severe harm to subjects, and when occurring in combination, synergistic potentiation effects can occur. As the standard in vitro pyrogen test, the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.