Evidence map›Paper›PMID 35491534›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022

A Stereocontrolled Total Synthesis of Lipoxin B4 and its Biological Activity as a Pro-Resolving Lipid Mediator of Neuroinflammation.

C Frank Lee, Carla E Brown, Alexander J Nielsen, Changmo Kim, Izhar Livne-Bar, Philip J Parsons, Christophe Boldron, François Autelitano, Donald F Weaver, Jeremy M Sivak and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Lipoxins AJournal of neuroinflammation · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

C Frank LeeCentre for Medicinal Chemistry and Drug Discovery, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Carla E BrownCentre for Medicinal Chemistry and Drug Discovery, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Alexander J NielsenCentre for Medicinal Chemistry and Drug Discovery, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Changmo KimDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Izhar Livne-BarDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Philip J ParsonsMolecular Sciences Research Hub, White City Campus, Imperial College London, London, United Kingdom.
Christophe BoldronCampus Curie, Evotec (France) SAS, Toulouse, France.
François AutelitanoCampus Curie, Evotec (France) SAS, Toulouse, France.
Donald F WeaverDepartment of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Jeremy M SivakDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Mark A ReedCentre for Medicinal Chemistry and Drug Discovery, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-0293-2691
University Health Network · CAImperial College London · GB

Funding

Homeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin CircuitR01EY030218 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, JOHN G, GRONERT, KARSTEN · 2020 to 2024
$2.4M
Candian Institutes of Health Research (CIHR) PJT166201National Institutes of Health (NIH) 5R01EY030218-03NEI NIH HHS R01 EY030218Toronto Innovation Acceleration Partners (TIAP) Lab150 PogramUHN Foundation
6 · The paper itself

Abstract

Two stereocontrolled, efficient, and modular syntheses of eicosanoid lipoxin B4 (LXB

Indexed as

LipoxinsNeuroinflammatory DiseasesEicosanoidsHumansEicosanoidslipoxin B4Lipoxinslipoxinsnatural productsneuroinflammationpro-resolving lipid mediatorstotal synthesis

Identifiers

PMID35491534
PMCPMC9891714
OpenAlexW4225278987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.