Evidence map›Paper›PMID 35491474›Full record

ArticleAlcoholism, clinical and experimental research2022

Stability and change in the interpretation of facial emotions in fetal alcohol spectrum disorders from childhood to adolescence.

Nadine M Lindinger, Joseph L Jacobson, Neil C Dodge, Susan Malcolm-Smith, Christopher D Molteno, Ernesta M Meintjes, Sandra W Jacobson

Open access · hybridAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Reading impairment in adolescents with fetal alcohol spectrum disorders.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nadine M LindingerChild Development Research Laboratory, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4148-2643
Joseph L JacobsonChild Development Research Laboratory, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-8271-280X
Neil C DodgeDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA.
Susan Malcolm-SmithACSENT Laboratory, Department of Psychology, Faculty of Humanities, University of Cape Town, Cape Town, South Africa.
Christopher D MoltenoDepartment of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Ernesta M MeintjesChild Development Research Laboratory, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Sandra W JacobsonChild Development Research Laboratory, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-9768-2671
University of Cape Town · ZAWayne State University · US

Funding

FASD Diagnostic Telemedicine ResourceU24AA014815 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lauren Gist, SARAH N MATTSON WELLER · 2003 to 2026
$5.6M
Neural Bases of Eyeblink Conditioning in FASDR01AA016781 · NIAAA · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W. · 2008 to 2012
$2.5M
FETAL ALCOHOL EXPOSURE AND SCHOOL-AGE COGNITIVE FUNCTIONR01AA009524 · NIAAA · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W. · 1993 to 2003
$1.5M
Behavioral Characteristics and Neural Correlates of Reading Impairment in FASDU01AA023503 · NIAAA · WAYNE STATE UNIVERSITY · PI GAAB, NADINE, JACOBSON, SANDRA W. · 2015 to 2017
$980k
Behavioral Characteristics and Neural Correlates of Reading Impairment in FASDR01AA023503 · NIAAA · WAYNE STATE UNIVERSITY · PI GAAB, NADINE, JACOBSON, SANDRA W. · 2018 to 2019
$640k
Identification of FASD in South African ChildrenU01AA014790 · NIAAA · WAYNE STATE UNIVERSITY · PI JACOBSON, SANDRA W. · 2003 to 2005
$501k
NIAAA NIH HHS R01 AA009524NIAAA NIH HHS R01 AA016781NIAAA NIH HHS R01 AA023503NIAAA NIH HHS U01 AA014790NIAAA NIH HHS U01 AA023503NIAAA NIH HHS U24 AA014815
6 · The paper itself

Abstract

backgroundThe ability to identify and interpret facial emotions plays a critical role in effective social functioning, which may be impaired in individuals with fetal alcohol spectrum disorders (FASD). We previously reported deficits in children with fetal alcohol syndrome (FAS) and partial FAS (PFAS) on the "Reading the Mind in the Eyes" (RME) test, which assesses the interpretation of facial emotion. This follow-up study in adolescents was designed to determine whether this impairment persists or represents a developmental delay; to classify the RME stimuli by valence (positive, negative, or neutral) and determine whether RME deficits differ by affective valence; and to explore how components of executive function mediate these associations.

methodsThe RME stimuli were rated and grouped according to valence. Sixty-two participants who had been administered the RME in late childhood (mean ± SD = 11.0 ± 0.4 years) were re-administered this test during adolescence (17.2 ± 0.6 years). Overall and valence-specific RME accuracy was examined in relation to prenatal alcohol exposure (PAE) and FASD diagnosis.

resultsChildren with FAS (n = 8) and PFAS (n = 15) performed more poorly on the RME than non-syndromal heavily exposed (HE; n = 19) and control individuals (n = 20). By adolescence, the PFAS group performed similarly to HE and controls, whereas the FAS group continued to perform more poorly. No deficits were seen for positively valenced items in any of the groups. For negative and neutral items, in late childhood individuals with FAS and PFAS performed more poorly than HE and controls, but by adolescence only the FAS group continued to perform more poorly. Test-retest reliability was moderate across the two ages. At both timepoints, the effects in the FAS group were partially mediated by Verbal Fluency but not by other aspects of executive function.

conclusionsIndividuals with full FAS have greater difficulty interpreting facial emotions than those with non-syndromal HE and healthy controls in both childhood and adolescence. By contrast, RME deficits in individuals with PFAS in childhood represent developmental delay.

Indexed as

Fetal Alcohol Spectrum DisordersFluorocarbonsPrenatal Exposure Delayed EffectsAdolescentChildEmotionsFemaleFollow-Up StudiesHumansPregnancyReproducibility of ResultsFluorocarbonsfetal alcohol spectrum disordersfetal alcohol syndromeprenatal alcohol exposureReading the Mind in the Eyessocial cognition

Identifiers

PMID35491474
PMCPMC9357050
OpenAlexW4225285097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.