Evidence map›Paper›PMID 35491398›Full record

ArticleChemMedChem2022

Spirooxindol-1,3-oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization.

Annika Eichhorst, Malte Gallhof, Alice Voss, Anett Sekora, Leon Eggers, Le Thi Huyen, Christian Junghanss, Hugo Murua Escobar, Malte Brasholz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annika EichhorstDepartment of Internal Medicine, Medical Clinic III, Clinic for Hematology, Oncology and Palliative Care, University Medical Center Rostock, Ernst-Heydemann-Strasse 6, 18057, Rostock, Germany.ORCID 0000-0002-8094-1200
Malte GallhofInstitute of Chemistry - Organic Chemistry, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.
Alice VossInstitute of Chemistry - Organic Chemistry, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.
Anett SekoraDepartment of Internal Medicine, Medical Clinic III, Clinic for Hematology, Oncology and Palliative Care, University Medical Center Rostock, Ernst-Heydemann-Strasse 6, 18057, Rostock, Germany.
Leon EggersDepartment of Internal Medicine, Medical Clinic III, Clinic for Hematology, Oncology and Palliative Care, University Medical Center Rostock, Ernst-Heydemann-Strasse 6, 18057, Rostock, Germany.
Le Thi HuyenVietnam National University, Hanoi University of Science, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.
Christian JunghanssDepartment of Internal Medicine, Medical Clinic III, Clinic for Hematology, Oncology and Palliative Care, University Medical Center Rostock, Ernst-Heydemann-Strasse 6, 18057, Rostock, Germany.
Hugo Murua EscobarDepartment of Internal Medicine, Medical Clinic III, Clinic for Hematology, Oncology and Palliative Care, University Medical Center Rostock, Ernst-Heydemann-Strasse 6, 18057, Rostock, Germany.ORCID 0000-0001-7123-7986
Malte BrasholzInstitute of Chemistry - Organic Chemistry, University of Rostock, Albert-Einstein-Str. 3 A, 18059, Rostock, Germany.ORCID 0000-0001-8184-646X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spirooxindole-1,3-oxazines are a small and structurally unique class of spirooxindole alkaloids. To date, only four of these compounds have been isolated from natural sources, and their biological properties remained unknown thus far. Dioxyreserpine is a synthetic spirooxindole-1,3-oxazine, that can readily be prepared from the Rauvolfia alkaloid (-)-reserpine by catalytic photooxygenation. While dioxyreserpine itself was now identified as a moderately effective antitumoral agent, structurally modified analogs of it emerged as a new class of highly potent and selective growth inhibitors of various human cancers, including pancreatic cancers. Systematic structural optimization ultimately led to an inhibitor displaying low-micromolar IC

Indexed as

AlkaloidsAntineoplastic AgentsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureOxazinesStructure-Activity RelationshipAlkaloidsAntineoplastic AgentsOxazinesantiproliferative agentsapoptosiscell cycleheterocyclesspirooxindoles

Identifiers

PMID35491398
PMCPMC9400852

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.