ArticleJournal of neuroendocrinology2022
Elevated prolactin secretion during proestrus in mice: Absence of a defined surge.
Article in Journal of neuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Defining functional puberty in female C57BL/6J mice using endocrine, cytological and morphological markers.Scientific reports · 2026Article
- Article
- Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice.Nature metabolism · 2025Article
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Prolactin blood concentration relies on the scalability of the TIDA neurons' network efficiencyiScience · 2024Article
- Multiple cell types in the oviduct express the prolactin receptor.FASEB bioAdvances · 2022Article
- Elevated prolactin secretion during proestrus in mice: Absence of a defined surge.Journal of neuroendocrinology · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
Throughout the reproductive cycle in rodents, prolactin levels are generally low. In some species, including rats, a prolactin surge occurs on proestrus with peak concentrations coinciding with the preovulatory luteinizing hormone (LH) surge. In mice, however, there are conflicting reports relating to the occurrence and timing of a proestrous prolactin surge. To gain further insight into the incidence and characteristics of this surge in mice, we have used serial tail tip blood sampling and trunk blood collection from both C57BL/6J (inbred) and Swiss Webster (outbred) mouse strains to build a profile of prolactin secretion during proestrus in individual mice. A clearly defined LH surge was detected in most animals, suggesting the blood sampling approach was suitable for detecting patterns of hormone secretion on proestrus. Despite this, levels of prolactin were quite variable between individuals. Overall both mouse strains showed a generalized rise in prolactin levels on the day of proestrus compared with levels seen in diestrus. This pattern is quite distinct from the discreet, circadian-entrained surge observed in rats.
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